1- Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran , el.zarenezhad@gmail.com 2- Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran 3- Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ,Research Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran 4- Department of Persian Medicine, Fasa University of Medical Sciences, Fasa, Iran
Abstract: (160 Views)
Background: 3,2,1 triazoles are an important class of five-membered heterocyclic compounds whose unique biological properties have made them an important class of chemical compounds. The biological activity of these compounds is known as anti-fungal, anti-bacterial, anti-tumor, anti-inflammatory, anti-depressant, anti-tuberculosis, anti-HIV, etc. Materials and methods: In this research, first we synthesized new courcomin catalyst. We investigated synthesis of some 1,2,3 triazol derivatives and evaluated their anti-bacterial and anti-fungal effects. After synthesis and purification ofsome 1,2,3-triazol compound, the inhibitory effect of compounds against fungal (Candidaalbicans, Aspergillus niger) and against bacterial (Staphylococcus arueus and Escherichia coli) was evaluated. Results: It was found that compound (3): 1-(4-bromobenzyl)-1H-1,2,3-triazol-4-ol exhibited the best antifungal activities. Also this compound showed good activity against Staphylococcus areus as a Gram-positive bacteria. Conclusion: According to the results, it seems that the use of recombinant substance 3 as a new compound with acceptable antimicrobial properties can be considered
Zarenezhad E, Ghasemian A, Iraji A, Rostami chijan M, Kazemi M, Haghjoo E. Synthesis of 1-aryl 4-phenyl 1,2,3-triazols and Investigating Anti-Fungal and Anti-Bacterial Activity in In Vitro Conditions. MEDICAL SCIENCES 2024; 34 (1) :46-55 URL: http://tmuj.iautmu.ac.ir/article-1-2116-en.html