Medical Sciences Journal of Islamic Azad University
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی تهران
MEDICAL SCIENCES
Medical Sciences
http://tmuj.iautmu.ac.ir
1
admin
1023-5922
2008-3386
000
10.61186/iau
000
1023-5922
000
fa
jalali
1390
3
1
gregorian
2011
6
1
21
1
online
1
fulltext
fa
بررسی همبستگی پلیمورفیسم جایگاههای BsmIو FokIژن گیرنده ویتامین D با خطر سرطان روده بزرگ در بیماران ایرانی مراجعه کننده به بیمارستان طالقانی تهران
Evaluation of the association between FokI and BsmI polymorphisms of vitamin D receptor gene and risk of colorectal cancer in Iranian patients referred to Taleghani hospital, Tehran
زيست شناسي مولكولي
Molecular Biology
موردي- شاهدي
case-control
<p style="LINE-HEIGHT: normal MARGIN: 0in 0in 0pt" dir="rtl" class="a" align="justify"><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt mso-bidi-language: FA mso-bidi-font-weight: bold mso-no-proof: yes" lang="FA"><font face="Tahoma">z</font><strong>سابقه و هدف</strong></span><i><span style="FONT-FAMILY: Nazanin LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-bidi-language: FA mso-no-proof: yes" lang="FA">:</span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt mso-ansi-font-weight: bold" lang="FA"> </span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt mso-ansi-font-weight: bold" lang="AR-SA">ارتباط پلیمورفیسمهای ژن گیرنده ویتامین </span></i><font face="Times New Roman"><i><span style="LETTER-SPACING: -0.3pt FONT-SIZE: 10pt FONT-WEIGHT: normal mso-bidi-language: FA mso-bidi-font-weight: bold mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr">D</span></i><span dir="rtl"></span></font><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt mso-ansi-font-weight: bold" lang="AR-SA"><span dir="rtl"></span> و سرطان روده بزرگ، سینه و پروستات مشخص شده است. در این مطالعه همبستگی دو پلیمورفیسم ژن </span></i><font face="Times New Roman"><i><span style="LETTER-SPACING: -0.3pt FONT-SIZE: 10pt FONT-WEIGHT: normal mso-bidi-language: FA mso-bidi-font-weight: bold mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr">VDR</span></i><span dir="rtl"></span></font><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt mso-ansi-font-weight: bold" lang="AR-SA"><span dir="rtl"></span> در جایگاه</span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-weight: bold" lang="AR-SA"></span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt mso-ansi-font-weight: bold" lang="AR-SA">های برش آنزیمی </span></i><font face="Times New Roman"><i><span style="LETTER-SPACING: -0.3pt FONT-SIZE: 10pt FONT-WEIGHT: normal mso-bidi-language: FA mso-bidi-font-weight: bold mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr">BsmI</span></i><span dir="rtl"></span></font><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt mso-ansi-font-weight: bold" lang="AR-SA"><span dir="rtl"></span> و </span></i><font face="Times New Roman"><i><span style="LETTER-SPACING: -0.3pt FONT-SIZE: 10pt FONT-WEIGHT: normal mso-bidi-language: FA mso-bidi-font-weight: bold mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr">FokI</span></i><span dir="rtl"></span></font><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt mso-ansi-font-weight: bold"><span dir="rtl"></span> </span></i><span dir="ltr"></span><i><span style="LETTER-SPACING: -0.3pt FONT-SIZE: 10pt mso-bidi-language: FA mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr"><span dir="ltr"></span><span style="mso-spacerun: yes"><strong><font size="2" face="Times New Roman"> </font></strong></span></span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt mso-ansi-font-weight: bold" lang="AR-SA">با خطر ابتلا به سرطان روده بزرگ بیماران ایرانی بررسی شد</span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-bidi-language: FA mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="FA">.</span></i><i><span style="LETTER-SPACING: -0.3pt FONT-SIZE: 12pt mso-bidi-language: FA mso-no-proof: yes mso-bidi-font-family: 'B Nazanin'" dir="ltr"><p></p></span></i></p><p style="LINE-HEIGHT: normal MARGIN: 0in 0in 0pt" dir="rtl" class="a"><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt mso-bidi-language: FA mso-bidi-font-weight: bold mso-no-proof: yes" lang="FA"><strong>روش بررسی</strong></span><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-bidi-language: FA mso-no-proof: yes" lang="FA">: </span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA">در این مطالعه مورد- شاهدی، 110 نمونه </span></i><font face="Times New Roman"><i><span style="LETTER-SPACING: -0.3pt FONT-SIZE: 10pt FONT-WEIGHT: normal mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr">DNA</span></i><span dir="rtl"></span></font><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA"><span dir="rtl"></span> افراد مبتلا به سرطان روده بزرگ و 110 نمونه افراد شاهد سالم جمع</span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-weight: bold" lang="AR-SA"></span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA">آوری شد.</span></i><span dir="ltr"></span><i><span style="LETTER-SPACING: -0.3pt FONT-SIZE: 10pt FONT-WEIGHT: normal mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr" lang="AR-SA"><span dir="ltr"></span><font face="Times New Roman"> </font></span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA">تعیین ژنوتیپ به روش </span></i><font face="Times New Roman"><i><span style="LETTER-SPACING: -0.3pt FONT-SIZE: 10pt FONT-WEIGHT: normal mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr">PCR-RFLP</span></i><span dir="rtl"></span></font><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA"><span dir="rtl"></span> انجام شد و برای تأئید نتایج </span></i><font face="Times New Roman"><i><span style="LETTER-SPACING: -0.3pt FONT-SIZE: 10pt FONT-WEIGHT: normal mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr">RFLP</span></i><span dir="rtl"></span></font><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA"><span dir="rtl"></span>، ژنوتایپ پنج درصد آنها با روش تعیین توالی مستقیم تعیین شد.</span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-bidi-language: FA mso-no-proof: yes" lang="AR-SA"> </span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.3pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-bidi-language: FA mso-no-proof: yes" lang="FA"><p></p></span></i></p><p style="LINE-HEIGHT: normal MARGIN: 0in 0in 0pt" dir="rtl" class="a"><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.2pt FONT-SIZE: 12pt mso-bidi-language: FA mso-bidi-font-weight: bold mso-no-proof: yes" lang="FA"><strong>یافته</strong></span><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.2pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-bidi-language: FA mso-no-proof: yes mso-ansi-font-weight: bold" lang="FA"></span><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.2pt FONT-SIZE: 12pt mso-bidi-language: FA mso-bidi-font-weight: bold mso-no-proof: yes" lang="FA"><strong>ها:</strong></span><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal" lang="FA"> </span><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA">فراوانی در پلی</span></i><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-weight: bold" lang="AR-SA"></span></i><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA">مورفیسم</span></i><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-weight: bold" lang="AR-SA"></span></i><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA">های جایگاه</span></i><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-weight: bold" lang="AR-SA"></span></i><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA">های </span></i><font face="Times New Roman"><i><span style="FONT-SIZE: 10pt FONT-WEIGHT: normal mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr">BsmI</span></i><span dir="rtl"></span></font><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA"><span dir="rtl"></span> و </span></i><font face="Times New Roman"><i><span style="FONT-SIZE: 10pt FONT-WEIGHT: normal mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr">FokI</span></i><span dir="rtl"></span></font><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA"><span dir="rtl"></span> ژن گیرنده ویتامین </span></i><font face="Times New Roman"><i><span style="FONT-SIZE: 10pt FONT-WEIGHT: normal mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr">D</span></i><span dir="rtl"></span></font><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA"><span dir="rtl"></span> میان بیماران و افراد شاهد سالم تا حد زیادی مشابه بود.</span></i><span dir="ltr"></span><i><span style="FONT-SIZE: 10pt FONT-WEIGHT: normal mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin'" dir="ltr" lang="AR-SA"><span dir="ltr"></span><font face="Times New Roman"> </font></span></i><span dir="rtl"></span><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA"><span dir="rtl"></span><font size="3"><font face="B Nazanin"><span style="mso-spacerun: yes"> </span>توزیع اللی نیز در هر دو گروه مشابه گزارش شد. از لحاظ آماری تفاوت معنی</font></font></span></i><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-weight: bold" lang="AR-SA"></span></i><i><span style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt FONT-WEIGHT: normal mso-no-proof: yes mso-ansi-font-size: 10.0pt" lang="AR-SA">داری میان بیماران دو گروه یافت نشد.</span></i><i><span style="FONT-FAMILY: 'B Nazanin' LETTER-SPACING: -0.2pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-bidi-language: FA mso-no-proof: yes" lang="AR-SA"> </span></i><i><span style="LETTER-SPACING: -0.2pt FONT-SIZE: 12pt FONT-WEIGHT: normal mso-bidi-language: FA mso-no-proof: yes mso-bidi-font-family: 'B Nazanin'" dir="ltr"><p></p></span></i></p><p style="DIRECTION: rtl" align="justify"><span><span style="FONT-FAMILY: 'Times New Roman','serif' FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-no-proof: yes mso-bidi-font-size: 12.0pt mso-bidi-font-family: 'B Nazanin' mso-fareast-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US"><em><font size="3"> <strong>نتیجه گیری: </strong>میان پلی مورفیسم Bsml و FokI ژن گیرنده ویتامین D وخطر سرطان روده بزرگ در بیماران ایرانی رابطه معنی داری وجود ندارد . برای تائید این نتایج وتعمیم آن به همه جمعیت ایرانی به انجام مطالعات گسترده با حجم نمونه بالاتری نیاز است.</font></em></span></span></p>
<p><strong>Background:</strong> There are several studies that have identified relationship between VDR gene polymorphisms and colorectal (CRC) or other kinds of cancers, such as breast and prostate cancers. The aim of our study was to evaluate the association of VDR gene polymorphisms, BsmI and FokI, with colorectal cancer risk among Iranian patients. </p><p><strong>Materials and methods</strong>: In this case-control study, 110 DNA samples from Iranian CRC patients and 110 samples from healthy Iranian people. Genotyping of BsmI and FokI polymorphisms were performed by PCR-RFLP method. To confirm the RFLP results, 5% of samples were sequenced with direct sequencing method. </p><p><strong>Results</strong>: The frequency of the VDR gene polymorphisms at BsmI and FokI restriction sites in CRC patients and healthy controls was almost similar. Allele distribution in patients and controls was same. There was no statistically significant difference in genotype or allele frequency between CRC patients and control group. </p><p><strong>Conclusion:</strong> VDR FokI and BsmI genotypes are not associated with increased risk of colorectal cancer in Iranian patients. However, these data remain to be confirmed by studies with larger sample size in Iran </p>
BsmI، FokI، گیرنده ویتامین D، سرطان روده بزرگ
BsmI, FokI, Vitamin D receptor, Colorectal cancer
55
60
http://tmuj.iautmu.ac.ir/browse.php?a_code=A-10-155-4&slc_lang=fa&sid=1
Pedram
Azimzadeh
پدرام
عظیم زاده
Azimzadeh.pedram@yahoo.com
10031947532846002907
10031947532846002907
Yes
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
مرکز تحقیقات بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی
Mahdi
Montazerhaghighi
مهدی
منتظرحقیقی
10031947532846002908
10031947532846002908
No
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
مرکز تحقیقات بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی
Seyed Reza
Mohebbi
سیدرضا
محبی
10031947532846002909
10031947532846002909
No
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
مرکز تحقیقات بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی
Sara
Romani
سارا
رومانی
10031947532846002910
10031947532846002910
No
, Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
مرکز تحقیقات بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی
Seyed Reza
Fatemi
سیدرضا
فاطمی
10031947532846002911
10031947532846002911
No
Gastroenterologist, Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
مرکز تحقیقات بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی
Mohammad Amin
Pourhoseingholi
محمدامین
پورحسینقلی
10031947532846002912
10031947532846002912
No
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
مرکز تحقیقات بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی
Fatemeh
Nemati Malek
فاطمه
نعمتی ملک
10031947532846002913
10031947532846002913
No
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
مرکز تحقیقات بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی
Mohammad Reza
Zali
محمدرضا
زالی
10031947532846002914
10031947532846002914
No
Gastroenterologist, Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
مرکز تحقیقات بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی