TY - JOUR T1 - Anticancer effects of some Girard-P reagent-based schiff bases and ‎their Dimethyltin (IV) complexes on malignant glioblastoma cell line ‎in in vitro culture TT - خاصیت ضدسرطانی تعدادی باز شیف بر پایه معرف گیرارد-‌P‌ و کمپلکس دی ‌متیل قلع (‌IV‌)آنها بر رده سرطانی ‌U-87‎‌ در شرایط کشت آزمایشگاهی ‌ JF - iau-tmuj JO - iau-tmuj VL - 27 IS - 2 UR - http://tmuj.iautmu.ac.ir/article-1-1251-en.html Y1 - 2017 SP - 113 EP - 118 KW - Cancer KW - Schiff bases KW - Dimethyltin (IV) Complexes KW - U-87‎ N2 - Background: Glioblastoma (U-87) is the most common and most malignant of the glial tumors that ‎appeared in the central nervous system. This is the first study that has evaluated the cytotoxic effects ‎of various Girard-P reagent-based Schiff bases and their dimethyltin (IV) complexes on Glioblastoma ‎cell line, U-87, viability. ‎ Materials and methods: In this experimental study, U-87 cell line was grown in DMEM ‎supplemented with 10% FBS, penicillin/streptomycin (100 U/ml, 100 µg/ml) at 37 ◦C in 5% CO2, then ‎the effects of different concentrations of complexes on Glioblastoma cell were evaluated by MTT and ‎DAPI staining. ‎ Results: Herein, we demonstrated that these compounds had cytotoxicity effects of Glioblastoma ‎cancer cells. In a dose dependent manner, a significant cytotoxicity was observed with increasing of ‎P1M and P3. ‎ Conclusion: The results showed that Girard-P reagent-based Schiff bases and their dimethyltin (IV) ‎complexes have the ability to induce cytotoxicity in the Glioblastoma cancer cell line in lower mg/ml ‎concentrations. In conclusion, these findings may introduce a new view on the mode of action and ‎possible application of new compounds in the cancer chemotherapy.‎ Keywords: Cancer, Schiff bases, Dimethyltin (IV) Complexes, U-87‎ M3 ER -