AU - Borzu, Zahra AU - Edalatmanesh, Mohammad Amin TI - The evaluation of hippocampal level of brain derived neurotrophic ‎factor and spatial memory in valproic acid animal model of autism PT - JOURNAL ARTICLE TA - iau-tmuj JN - iau-tmuj VO - 27 VI - 2 IP - 2 4099 - http://tmuj.iautmu.ac.ir/article-1-1249-en.html 4100 - http://tmuj.iautmu.ac.ir/article-1-1249-en.pdf SO - iau-tmuj 2 AB  - Background: Autism, a behavior-developmental disorder, is characterized by impairments in social ‎interaction, communications, as well as restricted, repetitive, and stereotyped patterns of behavior. The ‎studies revealed changes in hippocampal level of brain-derived neurotrophic factor (BDNF) in autism ‎etiology. However, their level and mechanism of action are needed to be elucidated. This study aimed ‎to determine the hippocampal levels of BDNF and its relation with spatial memory in valproic acid ‎animal model of autism. ‎ Materials and methods:‎‌ ‌In this experimental study, 40 male and female Sprague Dawley rat pups ‎were divided into two Phosphate-Buffered Saline receiver (PBS, n=20) and Valproic Acid receiver ‎‎(VPA, n=20) groups. VPA model of autism was induced by intra-peritoneal administration of VPA ‎‎(500 mg/kg) at 12.5 days after gestation. To measure changes in spatial memory Morris water maze ‎test was used. Then, the hippocampal levels of BDNF were determined by ELISA method. ‎ Results: Increased spatial memory was observed in Morris water maze test among VPA group ‎compared to PBS group. In addition, the hippocampal levels of BDNF in VPA rats were significantly ‎higher than PBS group (p CP - IRAN IN - Physiology, Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran ‎ LG - eng PB - iau-tmuj PG - 97 PT - Experimental YR - 2017