AU - Khorsandi, Laya Sadat AU - Hashemitabar, Mahmood AU - Orazizadeh, Mahmood TI - The study of Bax protein expression in Dexamethasone induced apoptosis in spermatogenic cells in mice PT - JOURNAL ARTICLE TA - iau-tmuj JN - iau-tmuj VO - 18 VI - 3 IP - 3 4099 - http://tmuj.iautmu.ac.ir/article-1-151-en.html 4100 - http://tmuj.iautmu.ac.ir/article-1-151-en.pdf SO - iau-tmuj 3 ABĀ  - Background: Some studies have shown that glucocorticoids affect testis homeostasis by decreasing testosterone level. In this study the influence of dexametasone (Dex), a widely used glucocorticoid drug, was evaluated on expression of Bax protein in mice testicular germ cells and spermatogenesis process. Materials and Methods: In this experimental study thirty five adult male mice randomly divided into 5 groups. Test groups (T1-T4) received 2, 4, 7 and 10 mg/kg Dex per day for 7 days, respectively. Control group received only saline daily for 7 days. Then the mice were sacrificed and their testes were incubated in formalin for immunohistochemistry and histology studies. Results: T1 and T2 groups, which received 7 and 10 mg/kg Dex, showed significant decrease in the number of germ cells and somatic cells of testes, and also in the maturity of spermatogenesis (p CP - IRAN IN - Student of PhD of Histology, Faculty of Medicine, Ahwaz Jundi Shapour University of Medical Sciences, Ahwaz, Iran LG - eng PB - iau-tmuj PG - 141 PT - YR - 2008