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Anti bacterial scaffolds based on gum tragacanth for wound caring under moist conditions
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Ramin Khajavi   1, Maryam Hajmaleki2 , Farhad Shahmirzaei Ashtiyani3 , Tayebeh Toliat4 , Morteza Sattari5 , Mohammad Mirjalili |
1- Department of Textile Engineering, Islamic Azad University, South Tehran Branch, Tehran, Iran , khajavi@azad.ac.ir
2- MSc of Textile Engineering, Textile Chemistry and Fiber Sciences, Islamic Azad University, Science and Research Campus, Tehran, Iran
3- MSc of Textile Engineering, Textile Chemistry and Fiber Sciences, Islamic Azad University, Yazd Branch, Yazd, Iran
4- Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
5- Department of Bacteriology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran |
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Abstract: (26383 Views) |
Background: When hydrocolloids dressings are loaded with an antibacterial agent, they can also prevent infection during wound cicatrisation. To consider interesting properties of traditional Gum Tragacanth such as moisture absorption, hydrocolloid formation, drug holding and releasing abilities, it was aimed to introduce a scaffold wound dress based on Gum Tragacanth with drug release ability simultaneously.
Materials and Methods: In this experimental study, gum tragacanth from Astragalus gossypinus species (Iranian species) is solved and loaded with an aminoglycoside antibiotic (Gentamicin). Prepared solution transformed to a nano fibers network “scaffold” by lyophilization method. Samples were characterized by scanning electron microscopy, fourier transform infrared and X-ray diffraction methods and their antimicrobial and moisture holding properties were determined.
Results: Gum tragacanth showed a proper potential for dispersing gentamicin and the drug was loaded into polymer matrix without any aggregation. Loaded gum tragacanth with gentamicin is successfully transformed to a nanofibers scaffold by lyophilization. The diameters of fibers were in the range of 300nm to 2µm. Transformed gum tragacanth into scaffolds showed declined regain content (up to 50%) due to the ordering and orientation of polymer chains. Ordered hydroxyl groups also observed in FTIR graphs. Regarding the zones of inhibition, scaffolds also showed acceptable antibacterial activities.
Conclusion: Produced scaffolds are capable of absorbing wound’s exocrine liquid easily due to their high specific area of nanofibers. When it is turned to gel by moisture sorption, the release of loaded Gentamicin would be enhanced. |
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| Keywords: Gum tragacanth, Moist wound dressing, Scaffold, Gentamicin, Lyophilization |
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Full-Text [PDF 285 kb]
(7324 Downloads)
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Semi-pilot: Experimental |
Subject:
Chemistry
Received: 2013/09/22 | Published: 2013/09/15
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