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:: Volume 22, Issue 3 (Fall 2012) ::
MEDICAL SCIENCES 2012, 22(3): 211-215 Back to browse issues page
Factors affecting pregnancy and abortion rates following intra cytoplasmic sperm injection in the obstructive and non-obstructive azoospermic men
Elhamossadat Hashemian Naeini 1, Firoozeh Akbari asbagh 2, Mohammad Zare Niyestanak 3, Abdolrasool Mehrsay 4, Elham Foroozandeh 5, Mostafa Shokoohi 6, , Katayoun Berjis * 7
1- Gynecologist and Obstetrician, Mirza Koochak Khan Hospital, Tehran, Iran
2- Gynecologist and Obstetrician, Tehran University of Medical Sciences, Tehran, Iran
3- PhD Candidate of Psychology, Islamic Azad University, Naeen Branch, Naeen, Iran
4- Urologist, Tehran University of Medical Sciences, Tehran, Iran
5- PhD of Psychology, Islamic Azad University, Naeen Branch, Naeen, Iran
6- MSc of Epidemiology, Kerman University of Medical Sciences, Kerman, Iran
7- Gynecologist and Obstetrician, Fellowship of Infertility, Boo-Ali Hospital, Tehran, Iran , katayon.berjis@yahoo.com
Abstract:   (12130 Views)
Background: Intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of azoospermic men. The aim of this study was to evaluate the factors interfering in the success of ICSI, including sperm collection method, testicular histology, age and hormonal assay of the couple, the number of retrieved oocytes, and the number of transferred embryos.
Materials and methods: In this retrospective cohort study, 246 azoospemic men (52 with obstructive azoosprmia (OA) and 194 with non obstructive azoospermia (NOA)) who were underwent sperm retrieval with PESA or TESE and ICSI protocol were studied. By long protocol of ovarian stimulation, oocytes were retrieved 36h after hCG administration. After 48h, cleaved embryos were replaced in the uterine cavity.
Results: Clinical pregnancy rates (21.1% in OA versus 10.8% in NOA) was significantly correlated with sperm origin (P<0.05). Female partner’s age and serum FSH significantly influenced pregnancy rates in both groups (p<0.001) and also pregnancy rates was significantly influenced by number of retrieved oocytes and transferred embryos in NOA groups (P<0.05).
Conclusion: ICSI can make a chance for fertility in azoospermic men. Higher success rates in OA patients can be related to better quality of sperm. The value of male hormonal assay and testicular biopsy was not remarkable.
Keywords: Obstructive azoosprmia, Non obstructive azoospermia, ICSI, Clinical pregnancy rates
Full-Text [PDF 162 kb]   (1750 Downloads)    
Type of Study: Cohort | Subject: Gynecology
Received: 2012/09/23
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Hashemian Naeini E, Akbari asbagh F, Zare Niyestanak M, Mehrsay A, Foroozandeh E, Shokoohi M et al . Factors affecting pregnancy and abortion rates following intra cytoplasmic sperm injection in the obstructive and non-obstructive azoospermic men . MEDICAL SCIENCES. 2012; 22 (3) :211-215
URL: http://iau-tmuj.ir/article-1-594-en.html


Volume 22, Issue 3 (Fall 2012) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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