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:: Volume 22, Issue 2 (summer 2012) ::
MEDICAL SCIENCES 2012, 22(2): 116-121 Back to browse issues page
Analysis of endothelial nitric oxide synthase (eNOS) gene polymorphism Glu 298 Asp as a risk factor of coronary artery disease in a sample of Iranian population
Leili Rejali * 1, Mandana Hasanzad 2, Alireza Najafi 2, Mohamad Reza Mohammad Hassani 2, Meymanat Fathi 3, Mohammad Rezd Sarzaeim 4, Seyed Hamid Jamaledini 5, Mohammad Samzadeh 6
1- Young Researchers Club Member, Islamic Azad University, Tehran Medical Branch, Tehran, Iran , leili1367@yahoo.com
2- Islamic Azad University, Tehran Medical Branch, Tehran, Iran
3- Genetics Specialist, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
4- Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
5- PhD Student of Genetics, Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
6- Resident, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (12271 Views)
Background: Genetic factors contribute to the pathogenesis of Coronary artery disease (CAD). Among many polymorphisms of the eNOS gene, the Glu298Asp variant has implications in coronary artery disease (CAD). The aim of the present study was to investigate the association between CAD risk and Glu298Asp polymorphism of the eNOS gene.
Materials and Methods: In this case- control study, the eNOS gene polymorphism was analysed in 92 Iranian patients with coronary artery disease and 93control subjects. The Glu298Asp polymorphism of the endothelial nitric oxide synthase gene was determined by polymerase chain reaction and restriction fragment length polymorphism.
Results: There were significant differences between the control and patient groups for the eNOS3 genotypes. In addition, the family history of coronary artery disease, hypertension, dyslipidemia and eNOS TT genotype were independent risk factors of coronary artery disease. Those with TT genotypes hd 3.5 times (odds ratio = 3.57) risk of coronary artery disease compared with the control group.
Conclusion: These results suggest that coronary artery disease is associated with the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in our population.
Keywords: Coronary artery disease, Endothelial nitric oxide synthase, Genetic polymorphism
Full-Text [PDF 187 kb]   (2261 Downloads)    
Type of Study: case-control | Subject: Genetic
Received: 2012/06/27
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Rejali L, Hasanzad M, najafi A, Mohammad Hassani M R, Fathi M, Sarzaeim M R, et al . Analysis of endothelial nitric oxide synthase (eNOS) gene polymorphism Glu 298 Asp as a risk factor of coronary artery disease in a sample of Iranian population . MEDICAL SCIENCES. 2012; 22 (2) :116-121
URL: http://iau-tmuj.ir/article-1-566-en.html


Volume 22, Issue 2 (summer 2012) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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