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Histological, histometrical and thyroid hormones serum level evaluation after chronic nicotine exposure in mice
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Simin Fazelipoor   1, Mahsa Hadipour Jahromi2 , Negar Behtash3 , Zahra Tootiyan4 , Minoo Shafie5 , Fardin Asadi6 , Hamid Reza Chegini7 |
1- Associate Professor, Department of Anatomy, Islamic Azad University, Tehran Medical Branch, Tehran, Iran , simin_fazelipour@yahoo.com
2- Associate Professor, Department of Pharmacology, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
3- Medical Student, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
4- Associate Professor, Department of Anatomy, Faculty of Veterinary, Tehran University, Tehran, Iran
5- Assistant Professor, Department of Pathology, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
6- Assistant Professor, Department of Pediatrics, Zanjan University of Medical Sciences, Zanjan, Iran
7- Instructor, Department of Anatomy, Islamic Azad University, Tehran Medical Branch, Tehran, Iran |
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Abstract: (21907 Views) |
Background: Nicotine is an ingredient of cigarette smoke that has a lot of psychological and physical effects on addicted persons. The aim of this study was to evaluate nicotine effects on functional and histological alteration in thyroid gland that has important role on metabolic activities.
Materials and methods: In this experimental study, 40 mature male mice (25-30 gr) were divided to one control group and 3 experimental groups that received nicotine with dosage of 100, 200 and 400 µg/kg via oral gavage once a day for 60 days. Then, T3, T4 and TSH serum levels were measured and histomorphometric evaluation of thyroid gland was done.
Results: Significant decrease in body weight and thyroid follicular epithelial height and significant increase in serum level of T3 were noted.
Conclusion: This study showed that nicotine can cause alteration on metabolic activities of thyroid gland via the increase of T3 serum level and the decrease of follicular epithelial height. |
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| Keywords: Nicotine, Thyroid, Histology, Histometry |
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Full-Text [PDF 488 kb]
(3138 Downloads)
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Semi-pilot: Experimental |
Subject:
Anatomy
Received: 2012/02/15 | Published: 2012/02/15
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