[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 21, Issue 2 (summer 2011) ::
MEDICAL SCIENCES 2011, 21(2): 71-81 Back to browse issues page
Aurora kinases function in cell cycle and cancer treatment
Mohammad Reza Noori-Daloii 1, Ali Zekri2
1- Tehran University of Medical Sciences, Tehran, Iran , nooridaloii@sina.tums.ac.ir
2- MSc Student of Human Genetics
Abstract:   (20614 Views)
Abstract The Cell cycle of eukaryotes is an ordered set of events, culminating in cell growth and division into two daughter cells. Cell cycle consists of G1, S, G2 and M phases. M phase is divided to five sub-phases of prophase, prometaphase, metaphase, anaphase and telophase. At the end, two daughter cells are separated by cytokinesis. Cell cycle has checkpoints that ensure passage through different steps. Mutation or over- expression into genes coding checkpoint proteins can cause cancer. Regulation of mitosis process is controlled by post translation in some protein kinases. CyclinB/Cdk1 initiates and makes progress mitosis. Some kinases, like Aurora kinases, NIMA and PLK, have vital role in mitosis. Aurora kinases have important roles in cell cycle, such as mitotic spindle assembly and metaphase chromosome bi-orientation. Aberrant expression of Aurora kinases can disrupt checkpoints and cause genomic instability to promote tumor initiation. Aurora kinase come in focus when they known as “Bona fida oncogens”. Human genome has three Aurora kinases, including Aurora kinases A, B, and C. Proteins with selective functions in cell cycle, especially cell cycle dependent kinases, are known as new drug targets for cancer treatment. Several studies have shown association of aurora kinases and malignancy so, they have been considered as a target for developing new drugs in the treatment of cancer. Increasing our knowledge about function and regulation of these magic kinases can lead us to develop drugs for cancer treatment
Keywords: Aurora kinases, Cell cycle, Cancer.
Full-Text [PDF 1045 kb]   (10859 Downloads)    
Semi-pilot: Review | Subject: Genetic
Received: 2011/09/11 | Published: 2011/09/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Noori-Daloii M R, Zekri A. Aurora kinases function in cell cycle and cancer treatment. MEDICAL SCIENCES 2011; 21 (2) :71-81
URL: http://tmuj.iautmu.ac.ir/article-1-446-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 21, Issue 2 (summer 2011) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
Persian site map - English site map - Created in 0.05 seconds with 37 queries by YEKTAWEB 4645