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:: Volume 20, Issue 1 (spring 2010) ::
MEDICAL SCIENCES 2010, 20(1): 6-9 Back to browse issues page
Studying cytotoxit effects of tolualdoxime on immature Balb/C mice spermatogenesis
Homa Mohseni Kouchesfahani , Mohammad Ali Bigdeli , Ghodrat Ebadi Manas , Kazem Parivar * 1
Abstract:   (20174 Views)
Background: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent attacks of fever and inflammation in the peritoneum, synovium, or pleura, accompanied by pain. In this study, we examined all 10 exons to determine the most common mutations in MEFV gene as a single gene associated with FMF.
Materials and methods: In this basic study, 51 clinically diagnosed Iranian FMF patients referred to Taleghani hospital were studied. Peripheral blood was gained from them and genomic DNA was extracted according to phenol chloroform standard protocol. They were screened for the MEFV mutation using bidirectional sequencing and finally, the sequences were analyzed by related soft wares.
Results: Of 51 patients suspected to FMF, 24 (47.05%) were positive for mutation and 27 (52.95%) had no mutations. 14 patients had M694V mutation in exon10 including 4 homozygote mutation ,8 heterozygote and 4 compound heterozygote. Moreover, we could find 6 patients with M680I mutation and 2 individual (8.3%) with V721I mutation in exon 10. Only one person carried E148Q heterozygote mutation in exon 2.
Conclusion:
Our finding were compatible with others investigation that M694V mutation is the most common mutation in different populations.
Keywords: Tolualdoxime, Cytotoxic effects, Spermatogenesis, Balb/C mice.
Full-Text [PDF 1375 kb]   (1684 Downloads)    
Subject: Epidemiology
Received: 2010/08/19
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Mohseni Kouchesfahani H, Bigdeli M A, Ebadi Manas G, Parivar K. Studying cytotoxit effects of tolualdoxime on immature Balb/C mice spermatogenesis . MEDICAL SCIENCES. 2010; 20 (1) :6-9
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Volume 20, Issue 1 (spring 2010) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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