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:: Volume 20, Issue 1 (spring 2010) ::
MEDICAL SCIENCES 2010, 20(1): 1-4 Back to browse issues page
Study of apoptosis induced by Calendula officinalis extract on experimental colon carcinoma in rats
Yousef Doustar * 1, Dariush Mohajeri , Fatheme Fathiazad , Ali Namvaran
Abstract:   (19151 Views)
Background: In vitro studies have demonstrated the anticancer effect of Calendula officinalis extract on tumor cell line derived from colorectal cancers. The inhibition ranged from 70-100%. The aim of this study was to evaluate the apoptosis in epiththelial displastic colon cells following treated with Calendula officinalis extract.
Materials and methods: In this experimental study, 56 wistar male rats with age of 12 weeks and 200-300g weight were allocated into two equal groups of treatment and control. For induction of colorectal carcinoma, these two groups were given 1,2-dimethylhydrazine (40mg/kg), as subcutaneous injection, twice a week for two weeks. Treatment group also was treated with Calendula officinalis extract (200mg/kg/day) orally for 10 weeks. After 10 weeks, distal parts of colon tissue were biopsied in both groups and 3-4 micron tissue section was prepared through TUNEL staining method.
Results: Immunohistopathological study reveals that apoptotic cells of displastic colon epithelial cells in treatment group were higher than control group. Mean difference between treatment and control groups were statistically significant (p<0.01). Conclusion: This study indicated that Calendula officinalis extract would be induced apoptosis of displastic colon cells in experimental colorectal carcinoma of rats.
Keywords: Apoptosis, Colorectal carcinoma, Calendula officinalis
Full-Text [PDF 1334 kb]   (2148 Downloads)    
Subject: Nutrition Sciences
Received: 2010/08/17
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Doustar Y, Mohajeri D, Fathiazad F, Namvaran A. Study of apoptosis induced by Calendula officinalis extract on experimental colon carcinoma in rats . MEDICAL SCIENCES. 2010; 20 (1) :1-4
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Volume 20, Issue 1 (spring 2010) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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