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:: Volume 28, Issue 1 (spring 2018) ::
MEDICAL SCIENCES 2018, 28(1): 1-15 Back to browse issues page
Genome editing from bench to clinic by CRISPR/Cas9
Mohammad Reza Noori-Daloii * 1, Saeedeh Kavoosi 2, Nazanin Rahimi Rad 2
1- Professor PhD of Medical Molecular Genetics, Department of Medical Genetics, School of Medicine, Tehran University of Medical science, Tehran, Iran , nooridaloii@sina.tums.ac.ir
2- MSc in Molecular Genetics
Abstract:   (563 Views)
Background: Engineered molecular scissors invention beside their ability to conduct site-specific modification of the genome hold great promise for effective functional analyses of genes, genomes and epigenomes. These technologies could improve researchers’ understanding of the molecular underpinnings of disease states and facilitate novel medical genetic therapeutic applications. The CRISPR/Cas9 system’s simplicity, facile engineering and amenability to multiplexing make it the system of choice for many applications. CRISPR/Cas9 has been used to generate disease models to study genetic diseases. It is expected that in the near future researchers will refinement this technology in various aspects of the CRISPR/Cas9 system, including the system’s precision, delivery and control over the outcome of the on-targrt activity during repair process. Here, we discuss the CRISPR/Cas9 history, type of CRISPR systems, the status of this technology in the field of genome editing and its use in new treatments for diseases such as genetics, cancer, etc.
 
Keywords: Cystic genome editing, CRISPR/Cas9, Targeting specificity, Novel therapies
Full-Text [PDF 521 kb]   (140 Downloads)    
Type of Study: Review | Subject: Genetic
Received: 2017/12/5 | Accepted: 2019/01/9 | Published: 2018/04/1
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Noori-Daloii M R, Kavoosi S, Rahimi Rad N. Genome editing from bench to clinic by CRISPR/Cas9. MEDICAL SCIENCES. 2018; 28 (1) :1-15
URL: http://iau-tmuj.ir/article-1-1367-en.html


Volume 28, Issue 1 (spring 2018) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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