:: Volume 27, Issue 3 (fall 2017) ::
MEDICAL SCIENCES 2017, 27(3): 171-177 Back to browse issues page
Protective effects of fish oil omega3 supplements and aqueous extract of Glycyrrhiza glabra root against changes of liver enzymes levels induced by thioacetamide in male rats
Davood Moghadamnia * 1, Davood Moghadamnia 2, Mokhtar Mokhtari 3, Saeed Khatamsaz 4
1- Ph.D in Animal Physiology , davood.moghadamnia@gmail.com
2- Ph.D in Animal Physiology
3- Department of Biology, Kazerun Branch
4- Department of Biology ,Kazerun Branch
Abstract:   (1747 Views)
Background: Thioacetamide is a liver toxin that causes centrilobular necrosis. In this study, the protective effect of fish oil omega3 supplements and aqueous extract of Glycyrrhiza glabra root against disorder in liver enzymes level induced by thioacetamide in male rats was investigated. Materials and methods: In this experimental study, 63 male rats were divided into 9 groups: The control group, the sham group, the thioacetamide group, the experimental groups 1-6. Experimental groups received a daily dose of 100, 200 and 300 mg/kg fish oil omega-3 supplements and the aqueous extract of Glycyrrhiza glabra root orally respectively for 3 month followed by an inter peritoneal dose of 150 mg/kg thioacetamide at the end of the experiment. The serum levels of SGOT, SGPT, ALP, GGT and LDH were measured. Results: The serum level of SGPT showed a significant decrease in the experimental groups 1, 5 and 6 compared to the group received thioacetamide. The serum level of GGT showed a significant decrease in the experimental groups 1, 2, 5 and 6 compared to the group received thioacetamide. The serum levels of SGOT, ALP and LDH in all experimental groups did not show significant changes compared to the group received thioacetamide (P<0.05). Conclusion: Fish oil omega3 supplements and aqueous extract of Glycyrrhiza glabra root had protective effects against disorder in liver enzymes level induced by thioacetamide in male rats. Keywords: Glycyrrhiza glabra root, Omega3, Thioacetamide , Liver enzymes, Male rats
Keywords: Glycyrrhiza glabra root, Omega3, Thioacetamide, Liver enzymes, Male rats
Full-Text [PDF 273 kb]   (254 Downloads)    
Type of Study: Experimental | Subject: Physiology
Received: 2016/10/5 | Accepted: 2016/12/26 | Published: 2017/09/20


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Volume 27, Issue 3 (fall 2017) Back to browse issues page