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:: Volume 27, Number 2 (summer 2017) ::
MEDICAL SCIENCES 2017, 27(2): 113-118 Back to browse issues page
Anticancer effects of some Girard-P reagent-based schiff bases and ‎their Dimethyltin (IV) complexes on malignant glioblastoma cell line ‎in in vitro culture
Elham hoveizi1, Zynab Ansariasl *2
1- Assistant Professor‎ Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2- Assistant Professor‎ Department of Chemistry, College of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Abstract:   (157 Views)
Background: Glioblastoma (U-87) is the most common and most malignant of the glial tumors that ‎appeared in the central nervous system. This is the first study that has evaluated the cytotoxic effects ‎of various Girard-P reagent-based Schiff bases and their dimethyltin (IV) complexes on Glioblastoma ‎cell line, U-87, viability. ‎ Materials and methods: In this experimental study, U-87 cell line was grown in DMEM ‎supplemented with 10% FBS, penicillin/streptomycin (100 U/ml, 100 µg/ml) at 37 ◦C in 5% CO2, then ‎the effects of different concentrations of complexes on Glioblastoma cell were evaluated by MTT and ‎DAPI staining. ‎ Results: Herein, we demonstrated that these compounds had cytotoxicity effects of Glioblastoma ‎cancer cells. In a dose dependent manner, a significant cytotoxicity was observed with increasing of ‎P1M and P3. ‎ Conclusion: The results showed that Girard-P reagent-based Schiff bases and their dimethyltin (IV) ‎complexes have the ability to induce cytotoxicity in the Glioblastoma cancer cell line in lower mg/ml ‎concentrations. In conclusion, these findings may introduce a new view on the mode of action and ‎possible application of new compounds in the cancer chemotherapy.‎ Keywords: Cancer, Schiff bases, Dimethyltin (IV) Complexes, U-87‎
Keywords: Cancer, Schiff bases, Dimethyltin (IV) Complexes, U-87‎
Full-Text [PDF 194 kb]   (67 Downloads)    
Type of Study: Experimental | Subject: Animal Biology
Received: 1901/12/14 | Accepted: 2017/03/6 | Published: 2017/06/19
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hoveizi E, Ansariasl Z. Anticancer effects of some Girard-P reagent-based schiff bases and ‎their Dimethyltin (IV) complexes on malignant glioblastoma cell line ‎in in vitro culture. MEDICAL SCIENCES. 2017; 27 (2) :113-118
URL: http://iau-tmuj.ir/article-1-1251-en.html
Volume 27, Number 2 (summer 2017) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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