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:: Volume 27, Number 2 (summer 2017) ::
Back to browse issues page MEDICAL SCIENCES 2017, 27(2): 97-104
The evaluation of hippocampal level of brain derived neurotrophic ‎factor and spatial memory in valproic acid animal model of autism
Zahra Borzu1, Mohammad Amin Edalatmanesh *2
1- MSc in Cell and Developmental Biology, Department of Biology, School of Sciences, Shiraz Branch, Islamic ‎Azad University, Shiraz, Iran
2- Assistant Professor Physiology, Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran ‎ , amin.edalatmanesh@gmail.com
Abstract:   (29 Views)
Background: Autism, a behavior-developmental disorder, is characterized by impairments in social ‎interaction, communications, as well as restricted, repetitive, and stereotyped patterns of behavior. The ‎studies revealed changes in hippocampal level of brain-derived neurotrophic factor (BDNF) in autism ‎etiology. However, their level and mechanism of action are needed to be elucidated. This study aimed ‎to determine the hippocampal levels of BDNF and its relation with spatial memory in valproic acid ‎animal model of autism. ‎ Materials and methods:‎‌ ‌In this experimental study, 40 male and female Sprague Dawley rat pups ‎were divided into two Phosphate-Buffered Saline receiver (PBS, n=20) and Valproic Acid receiver ‎‎(VPA, n=20) groups. VPA model of autism was induced by intra-peritoneal administration of VPA ‎‎(500 mg/kg) at 12.5 days after gestation. To measure changes in spatial memory Morris water maze ‎test was used. Then, the hippocampal levels of BDNF were determined by ELISA method. ‎ Results: Increased spatial memory was observed in Morris water maze test among VPA group ‎compared to PBS group. In addition, the hippocampal levels of BDNF in VPA rats were significantly ‎higher than PBS group (p<0.05). ‎ Conclusion: Increasing BDNF showed enhancement of spatial memory in VPA rat model of autism‎‌.‌ Keywords: Autism, Valproic acid, BDNF, Spatial memory.‎
Keywords: Autism, Valproic acid, BDNF, Spatial memory
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Type of Study: Experimental | Subject: Physiology
Received: 2016/10/8 | Accepted: 2016/12/12 | Published: 2017/06/19
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Borzu Z, Edalatmanesh M A. The evaluation of hippocampal level of brain derived neurotrophic ‎factor and spatial memory in valproic acid animal model of autism. MEDICAL SCIENCES. 2017; 27 (2) :97-104
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Back to browse issues page Volume 27, Number 2 (summer 2017)
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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