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:: Volume 27, Number 2 (summer 2017) ::
MEDICAL SCIENCES 2017, 27(2): 88-96 Back to browse issues page
The protective effect of ethanol extract of ginger (Zingiber ‎officinale) on spermatogenesis toxicity induced by doxorubicin‎
Fatemeh Juibar1, Mokhtar Mokhtari *2, Mehdi Dianatpur3, Mehrdad Shariatie4
1- PhD student, Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
2- Professor Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran , M.Mokhtari246@yahoo.com
3- Assistant Professor‎ Department of Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4- Associate Professor Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
Abstract:   (156 Views)
Background: DOX is one of the most common drugs used to treat different types of cancer, including ‎testicular cancer. The aim of this study was to evaluate the effect of ethanol extract of ginger on ‎spermatogenesis in rats. ‎ Materials and methods: In this experimental study, 56 male rats Wistar were randomly divided into 6 ‎groups of 8 animals control, the sham and experimental group 1 receiving doxorubicin (mg/kg.bw 3) ‎experimental 2 and 3 receiving ginger extract (500 , 1000 mg/ kg. bw ) and experimental 4 and 5 ‎received a ginger extract (500 , 1000 mg/ kg. bw ) + doxorubicin. The rats were fed extract daily, one ‎hour after doxorubicin injection, for four weeks. DOX (3mg/kg) was administered once a week ‎intraperitoneally. Some sperm parameters, such as the number, viability, morphology and mobility were ‎examined using Eosin-Ngrozin staining. ‎ Results: A significant decrease in body weight, sperm count, sperm motility, viability was observed in ‎drug-DOX-treated rats compared with the control group. The reduction in the group treated with DOX ‎with ginger 500 and 1000 mg/ kg significantly was offset compared with DOX. ‎ Conclusion: Ginger is able to have protective effect on sperm parameters in adult male rat induced by ‎Doxorobicin.‎ Keywords: Ginger, Doxorubicin, Body weight, Testes, Sperm parameters, Rat.‎
Keywords: Ginger, Doxorubicin, Body weight, Testes, Sperm parameters, Rat.‎
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Type of Study: Experimental | Subject: Physiology
Received: 2016/11/14 | Accepted: 2016/11/22 | Published: 2017/06/19
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Juibar F, Mokhtari M, Dianatpur M, Shariatie M. The protective effect of ethanol extract of ginger (Zingiber ‎officinale) on spermatogenesis toxicity induced by doxorubicin‎. MEDICAL SCIENCES. 2017; 27 (2) :88-96
URL: http://iau-tmuj.ir/article-1-1248-en.html
Volume 27, Number 2 (summer 2017) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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