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Assessment of vitamin D efficacy on treatment of symptoms of patients with peripheral diabetic neuropathy admitted to Amiralmomenin Hospital in Tehran in 2015
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Shabnam Hosseini   , Golaleh Asghari , Mojtaba Fallah , Massomeh Yarjanli 1, Sara Hasibi Taheri |
| 1- , massomeyarjanli@yahoo.com |
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Abstract: (5646 Views) |
| Background: Few studies have investigated the relationship between vitamin D deficiency and diabetic neuropathy. Present study aimed to investigate the effect of vitamin D in the treatment of diabetic peripheral neuropathy.
Materials and Methods: In this semi-experimental trial, 30 diabetic subjects aged over 35 years with peripheral neuropathy with serum levels of vitamin D less than 30ng/ml, were sequentially selected. The NSS questionnaire (Neuropathy Symptom Score) used to determine the severity of the symptoms of diabetic neuropathy (subjective data) and NDS questionnaire (Neuropathy Disability Score) used for symptoms of neuropathy (objective information). Participants were treated by 50,000 IU/week of oral vitamin D for 10 weeks.
Results: 30 patients with mean age of 60.1 years, including 10 (33%) men, were studied. 83.3% had serum vitamin D deficiency (under 20ng/mL) and 16.7% had serum vitamin D insufficiency (20-30ng/mL). Mean (± standard deviation) serum vitamin D levels was 14.37±5.86 ng/mL. Seventy percent of participants showed a significant decrease in NSS scores (p=0.02), as well as declining in mean of their scores (p<0.05) before and after the prescription of vitamin D. By contrast, there seems to be no significant changes in NDS scores at that interval (p=0.748).
Conclusion: Prescription of vitamin D for 3 months improved the symptoms of diabetic neuropathy in diabetic patients regarding NSS; however, NDS showed no changes in the examinations of participants.
Keywords: Vitamin D, Peripheral neuropathy, Diabetes. |
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| Keywords: Vitamin D, Peripheral neuropathy, Diabetes |
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Full-Text [PDF 227 kb]
(2216 Downloads)
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Semi-pilot: Quazi-Experimental |
Subject:
Metabolism and Endocrinology
Received: 2016/07/17 | Accepted: 2016/11/12 | Published: 2017/04/1
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