Background: Components of olive oil include oleic acid, hydrocarbons (as squalene), sterols (as beta-sitosterol), polyphenols (tyrosol, hydroxyltyrosol, oleuropeinand, and others), tocopherols and terpenoids. Olive oil ingredients have anti-inflammatory, antioxidant, anti-arrhythmic, anti-inflammatory and vasodilatory effects. The present study was done to evaluate the effects of olive oil on kidney, lipid and liver function in male rat.

Materials and methods: In this experimental study, 14 male rats were divided into 2 groups. In control group, each rat underwent no stress such as injection, oral gavage and etc. in experimental group, each rat received 0.4 mL olive oil orally per day for 3 months. All animals bled after 3 months. The blood samples were tested for creatinine, nitrogen urea blood (BUN), total cholesterol, LDL and HDL cholesterol, triglyceride, sodium, glucose, SGOT, SGPT, ALP, GGT, albumin and  total protein serum levels.

Results: No significant differences were noticed in sodium, BUN, total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride serum levels in rats treated with olive oil compared to control group. There were no significant differences in SGOT, SGPT, ALP, GGT, albumin and total protein serum levels between rats treated with olive oil and control group.

Conclusion: The results showed that olive oil had no effects on kidney, lipid and liver function.

Keywords: Olive oil, Kidney function, Lipid function, Liver function, Glucose, Male rat.