1. Reich DS, Lucchinetti CF, Calabresi PA. Multiple Sclerosis. N Engl J Med 2018;378:169-180. [DOI:10.1056/NEJMra1401483]

2. Filippi M, Brück W, Chard D, Fazekas F, Geurts JJG, Enzinger C, et al. Attendees of the Correlation between Pathological and MRI findings in MS workshop. Association between pathological and MRI findings in multiple sclerosis. Lancet Neurol 2019;18:198-210. [DOI:10.1016/S1474-4422(18)30451-4]

3. Henry A, Tourbah A, Camus G, Deschamps R, Mailhan L, Castex C, et al. Anxiety and depression in patients with multiple sclerosis: The mediating effects of perceived social support. Mult Scler Relat Disord 2019:27:46-51. [DOI:10.1016/j.msard.2018.09.039]

4. Belbasis L, Bellou V, Evangelou E, Ioannidis JP, Tzoulaki I. Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses. Lancet Neurol 2015;14:263-73. [DOI:10.1016/S1474-4422(14)70267-4]

5. Baranzini SE, Oksenberg JR. The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years. Trends Genet 2017;33:960-970. [DOI:10.1016/j.tig.2017.09.004]

6. Magyari M, Sorensen PS. The changing course of multiple sclerosis: rising incidence, change in geographic distribution, disease course, and prognosis. Curr Opin Neurol 2019;32:320-326. [DOI:10.1097/WCO.0000000000000695]

7. Kingwell E, Marriott JJ, Jetté N, Pringsheim T, Makhani N, Morrow SA, et al. Incidence and prevalence of multiple sclerosis in Europe: a systematic review. BMC Neurol 2013; 13:128. [DOI:10.1186/1471-2377-13-128]

8. Makhani N, Morrow SA, Fisk J, Evans C, Beland SG, Kulaga S, et al. MS incidence and prevalence in Africa, Asia, Australia and New Zealand: A systematic review. Mult Scler Relat Disord 2014;3:48-60. [DOI:10.1016/j.msard.2013.06.015]

9. Elhami SR, Mohammad K, Sahraian MA, Eftekhar H. A 20-year incidence trend (1989-2008) and point prevalence (March 20, 2009) of multiple sclerosis in Tehran, Iran: a population-based study. Neuroepidemiology 2011;36:141-7. [DOI:10.1159/000324708]

10. Etemadifar M, Janghorbani M, Shaygannejad V, Ashtari F. Prevalence of multiple sclerosis in Isfahan, Iran. Neuroepidemiology 2006;27:39-44. [DOI:10.1159/000094235]

11. Gilmour H, Ramage-Morin PL, Wong SL. Multiple sclerosis: Prevalence and impact. Health Rep 2018;29:3-8.

12. Eskandarieh S, Heydarpour P, Minagar A, Pourmand S, Sahraian MA. Multiple Sclerosis Epidemiology in East Asia, South East Asia and South Asia: A Systematic Review. Neuroepidemiology 2016;46:209-21. [DOI:10.1159/000444019]

13. Ashtari F, Rezvani R, Afshar H. Sexual dysfunction in women with multiple sclerosis: Dimensions and contributory factors. J Res Med Sci 2014;19:228-33.

14. Minden S, Frankel D. Plain talk: A Booklet about MS for Families. USA: National MS Society; 2014. Available from: https://www.nationalmssociety.org/Programs-and-Services/Resources/Plaintalk%E2%80%94A-Booklet-about-MS-for-Families-(-pdf).

15. Johnson KL, Bamer AM, Yorkston KM, Amtmann D. Use of cognitive aids and other assistive technology by individuals with multiple sclerosis. Disabil Rehabil Assist Technol 2009;4:1-8. [DOI:10.1080/17483100802239648]

16. Sedighi B. Memory impairment in multiple sclerosis and its determinant factors. Neurosciences (Riyadh) 2011;16:24-8.

17. Hancock L, Bruce J, Bruce A, Lynch S. Processing speed and working memory training in multiple sclerosis: a double-blind randomized controlled pilot study. J Clin Exp Neuropsychol 2015;37:113-27. [DOI:10.1080/13803395.2014.989818]

18. Shevil E, Finlayson M. Pilot study of a cognitive intervention program for persons with multiple sclerosis. Health Educ Res 2010;25:41-53. [DOI:10.1093/her/cyp037]

19. Badri Bagehjan S, Mohamadi feyzabadi A, Sharif Daramadi P, Fathabadi R. Effectiveness of Computer-Based Cognitive Rehabilitation on executive functions of children with High Functioning Autism. Empowering Exceptional Children 2020;11:52-41. [In Persian]

20. Veloso A, Vicente SG, Filipe MG. Effectiveness of Cognitive Training for School-Aged Children and Adolescents With Attention Deficit/Hyperactivity Disorder: A Systematic Review. Front Psychol 2020;10:2983. [DOI:10.3389/fpsyg.2019.02983]

21. Pham T, Jetté N, Bulloch AGM, Burton JM, Wiebe S, Patten SB. The prevalence of anxiety and associated factors in persons with multiple sclerosis. Mult Scler Relat Disord 2018;19:35-39. [DOI:10.1016/j.msard.2017.11.003]

22. Gaspari M, Zini F, Stecchi S. Enhancing cognitive rehabilitation in multiple sclerosis with a disease-specific tool. Disabil Rehabil Assist Technol 2023;18:313-326. [DOI:10.1080/17483107.2020.1849432]

23. Ressner P, Niliu P. Computer-Assisted Cognitive Rehabilitation in Stroke and Alzheimers disease. J Neurol Neurophysiol 2014;056. [DOI:10.4172/2155-9562.1000260]

24. Davoodi M, Shameli L, Hadianfard H. The Effectiveness of Acceptance and Commitment Therapy on Chronic Fatigue Syndrome and Pain Perception in People with Multiple Sclerosis. Iran J Psychiatry Clin Psychol 2019;25:250-65. [DOI:10.32598/ijpcp.25.3.250]

25. Harris R, Ed. ACT made simple: An easy-to-read primer on acceptance and commitment therapy. 2nd ed. Oakland, CA, US: New Harbinger Publications; 2019.

26. Geurts HM, Corbett B, Solomon M. The paradox of cognitive flexibility in autism. Trends Cogn Sci 2009;13:74-82. [DOI:10.1016/j.tics.2008.11.006]

27. Gökçen E, Petrides KV, Hudry K, Frederickson N, Smillie LD. Sub-threshold autism traits: the role of trait emotional intelligence and cognitive flexibility. Br J Psychol 2014;105:187-99. [DOI:10.1111/bjop.12033]

28. Eichorn N, Marton K, Pirutinsky S. Cognitive flexibility in preschool children with and without stuttering disorders. J Fluency Disord 2018 ;57:37-50. [DOI:10.1016/j.jfludis.2017.11.001]

29. Fanaee S, Habibollahi A, Ghazanfari A. Flexibility in individuals with overweight. Shenakht J Psychol Psych 2015;2:28-38. [In Persian]

30. Önen AS, Koçak C. The Effect of Cognitive Flexibility on Higher School Students' Study Strategies. Procedia Soc Behav Sci 2015;191:2346-50. [DOI:10.1016/j.sbspro.2015.04.680]

31. Grafe LA, Cornfeld A, Luz S, Valentino R, Bhatnagar S. Orexins Mediate Sex Differences in the Stress Response and in Cognitive Flexibility. Biol Psychiatry 2017;81:683-92. [DOI:10.1016/j.biopsych.2016.10.013]

32. Ortega LA, Tracy BA, Gould TJ, Parikh V. Effects of chronic low- and high-dose nicotine on cognitive flexibility in C57BL/6J mice. Behav Brain Res 2013;238:134-45. [DOI:10.1016/j.bbr.2012.10.032]

33. Stapleton T, Ashburn A, Stack E. A pilot study of attention deficits, balance control and falls in the subacute stage following stroke. Clin Rehab 2001;15:437-44. [DOI:10.1191/026921501678310243]

34. Bahramkhani M, Darvishi N, Keshavarz Z, Dadkhah A. The Camparison of Executive Functions in Normal and Autistic Children, Considering Mathematics and Reading Abilities. jrehab 2013;13:128-35. [In Persian]

35. Chiviacowsky S, Wulf G, Wally R. An external focus of attention enhances balance learning in older adults. Gait Posture 2010;32:572-5. [DOI:10.1016/j.gaitpost.2010.08.004]

36. Bogdanova Y, Yee MK, Ho VT, Cicerone KD. Computerized Cognitive Rehabilitation of Attention and Executive Function in Acquired Brain Injury: A Systematic Review. J Head Trauma Rehabil 2016;31:419-33. [DOI:10.1097/HTR.0000000000000203]

37. Bergo E, Lombardi G, Pambuku A, Della Puppa A, Bellu L, D'Avella D, et al. Cognitive Rehabilitation in Patients with Gliomas and Other Brain Tumors: State of the Art. Biomed Res Int 2016;2016:3041824-. [DOI:10.1155/2016/3041824]

38. O'Connell R, Bellgrove M, Robertson I. Avenues for the Neuro-Remediation of ADHD: Lessons from Clinical Neurosciences. In: Fitzgerald MBM, Gill M, eds. Handbook of Attention Deficit Hyperactivity Disorder. USA: Wiley-Blackwell; 2007. p. 441-63.

39. Messinis L, Nasios G, Kosmidis MH, Zampakis P, Malefaki S, Ntoskou K, et al. Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial. Behav Neurol 2017;2017:5919841. [DOI:10.1155/2017/5919841]

40. Shokoohi-Yekta M, Lotfi S, Rostami R, Arjmandnia AA, Motamed-Yeganeh N, Sharifi A. The effectiveness of computerized cognitive training on the working memory performance of children with dyslexia. Auditor Vestibul Res 2014;23.

41. Stathopoulou S, Lubar JF. EEG Changes in Traumatic Brain Injured Patients After Cognitive Rehabilitation. J Neurol 2004;8:21-51. [DOI:10.1300/J184v08n02_03]

42. Ghaedi G, Khalili M, Afshin-Majd S, Rahmati B, Karami M. Effectiveness of the computer-based cognitive training intervention on improvement of memory, attention and executive functions in veteran's children studying at the University of Shahed. Daneshvar Med 2020;25:31-44. [In Persian]

43. Dennis JP, Vander Wal JS. The Cognitive Flexibility Inventory: Instrument Development and Estimates of Reliability and Validity. Cog Ther Res 2010;34:241-53. [DOI:10.1007/s10608-009-9276-4]

44. Martin MM, Rubin RB. A New Measure of Cognitive Flexibility. Psychol Rep 1995;76:623-6. [DOI:10.2466/pr0.1995.76.2.623]

45. Roeen Fard M, Share H, Haghi E. The Effectiveness of Heimberg and Becker Cognitive Behavioral Group Therapy in Improving Female Adolescents Social Anxiety and Cognitive Flexibility. J Sabzevar Uni Med Sci 2014;21:226-40. [In Persian]

46. Sandford JA. Chapter 14 - Cognitive Training and Computers: An Innovative Approach. In: Fine AH, Kotkin RA, Eds. Therapist's Guide to Learning and Attention Disorders. San Diego: Academic Press; 2003. p. 421-41. [DOI:10.1016/B978-012256430-7/50016-8]

47. Sanford J, Browne R. Captain's Log (computer software). Richmond, VA: Braintrain. 1988. Avaiable from: https://scholar.google.com/scholar_lookup?title=Captain%27s+Log+%5BComputer+software%5D&publication_year=1988.

48. Irazoki E, Contreras-Somoza LM, Toribio-Guzmán JM, Jenaro-Río C, van der Roest H, Franco-Martín MA. Technologies for Cognitive Training and Cognitive Rehabilitation for People with Mild Cognitive Impairment and Dementia. A Systematic Review. Front Psychol 2020;11. [DOI:10.3389/fpsyg.2020.00648]

49. Royatvand Ghiasvand N, Amiri Majd M. Effectiveness of Captain's Log Cognitive Software on Visual-Spatial Perception of Students with Specific Learning Disorders. Res Inst Edu 2019;19:5-14. [In Persian]

50. Donders J, Hunter SJ. Introduction. In: Donders J, Hunter SJ, Eds. Neuropsychological Conditions across the Lifespan. Cambridge: Cambridge University Press; 2018. [DOI:10.1017/9781316996751]

51. Gross JJ, Thompson RA. Emotion Regulation: Conceptual Foundations. Handbook of emotion regulation. New York, NY, US: The Guilford Press; 2007. p. 3-24.

52. Pouramiri M, Azimian M, Akbarfahimi N, Pishyareh E, Hossienzadeh S. Investigating the Relationship Between Individual and Clinical Characteristics and Executive Dysfunction of Multiple Sclerosis Individuals. J Rehab 2019:114-23. [In Persian] [DOI:10.32598/rj.20.2.114]

53. Ghorbanian E, Alivandi Vafa M, Farhoudi M, Nazari MA. Effect of Computer-based Cognitive Rehabilitation Intervention on Selective Attention, Sustained Attention, and Divided Attention of Patients with Stroke in Tabriz. Sci J Rehabil Med 2020;9:137-46.

54. Amani O, Mazaheri MA, Nejati V, Shamsian BS. Effect of Cognitive Rehabilitation on Executive Functions in Adolescent Survivors of Leukemia: A Randomized and Controlled Clinical Trial. J Rehabil 2017;18:73-82. [In Persian] [DOI:10.21859/jrehab-180173]

55. Hassan Nattaj F, Taghipour Javan AA, Faramarzi S, Rastgar F. The Impact of Cognitive-Based Video Games on Executive Functions in Preschool Children with Neuropsychological Learning Disabilities. J Child Mental Health 2015;2:35-45. [In Persian]

56. Qamari Givi H, Nader M, Dehqani F. Clin Psychol Stu 2014;4:101-28. [In Persian]

57. Kesler S, Lacayo N, Jo B. A pilot study of an online cognitive rehabilitation program for executive function skills in children with cancer-related brain injury. Brain Inj 2011;25:101-12. [DOI:10.3109/02699052.2010.536194]

58. Holzer L, Urben S, Passini CM, Jaugey L, Herzog MH, Halfon O, et al. A Randomized Controlled Trial of the Effectiveness of Computer-Assisted Cognitive Remediation (CACR) in Adolescents with Psychosis or at High Risk of Psychosis. Behav Cog Psychol 2013;42:421-34. [DOI:10.1017/S1352465813000313]

59. Najarzadegan M, Nejati V, Amiri N. Effect of Cognitive Rehabilitation of Working Memory in Reducing Behavioral Symptoms (Attention Deficit and Impulsivity) of Children with Attention Deficit and Hyperactivity Disorder. Neuropsychol 2015;1:52-45. [In Persian]

60. Serino A, Ciaramelli E, Santantonio AD, Malagù S, Servadei F, Làdavas E. A pilot study for rehabilitation of central executive deficits after traumatic brain injury. Brain Inj 2007;21:11-9. [DOI:10.1080/02699050601151811]

61. Gaitán A, Garolera M, Cerulla N, Chico G, Rodriguez-Querol M, Canela-Soler J. Efficacy of an adjunctive computer-based cognitive training program in amnestic mild cognitive impairment and Alzheimer's disease: a single-blind, randomized clinical trial. Int J Geriatr Psychiatry 2013;28:91-9. [DOI:10.1002/gps.3794]

62. Bazzaz Monsef F, Soleymani M, Shalchi B. The Effectiveness of Neurocognitive Rehabilitation On the Math Performance and Working Memory of Students with Dyscalculia. Qom Uni Med Sci J 2017;11:63-75. [In Persian]

63. Sosa GW, Lagana L. The effects of video game training on the cognitive functioning of older adults: A community-based randomized controlled trial. Arch Gero Geriatr 2019;80:20-30. . [DOI:10.1016/j.archger.2018.04.012]

64. Homer BD, Plass JL, Raffaele C, Ober TM, Ali A. Improving high school students' executive functions through digital game play. Computers and education 2018;117:50-8. [DOI:10.1016/j.compedu.2017.09.011]

65. Fu X, Zhang J. The influence of strategy video game and its background music on cognitive control. Mental Health Addic Res 2017;2. [DOI:10.15761/MHAR.1000125]

66. Moynihan JA, Chapman BP, Klorman R, Krasner MS, Duberstein PR, Brown KW, et al. Mindfulness-based stress reduction for older adults: effects on executive function, frontal alpha asymmetry and immune function. Neuropsychobioly 2013;68:34-43. [DOI:10.1159/000350949]

67. Taghavi Jelodar M, Hami M. The Effectiveness of the Computer Games On Children's Problem-Solving Ability. Journal of Instruction and Evaluation 2018;11:55-70. [In Persian]

68. Abdi A, Arabani Dana A, Hatami J, Parand A. The Effect of Cognitive Computer Games on Working Memory, Attention and Cognitive Flexibility in Students with Attention Deficit/Hyperactivity Disorder. Except Child 2014;14:19-34. [In Persian]