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:: Volume 22, Number 1 (spring2012 2012) ::
MEDICAL SCIENCES 2012, 22(1): 1-11 Back to browse issues page
Effects of synchronized oral administration and topical application of Kombucha on third-degree burn wounds regeneration in mature rats
kazem parivar1, Parichehr Yaghmaie2, Nasim Hayati Rudbari3, Parastoo Mohammadi Mohaghegh *4
1- 1 Professor Islamic Azad University, Science and Research Campus, Tehran, Iran
2- Assistant Professor Islamic Azad University, Science and Research Campus, Tehran, Iran
3- Associate Professor Islamic Azad University, Science and Research Campus, Tehran, Iran
4- MSc student Islamic Azad University, Science and Research Campus, Tehran, Iran , parastoo.mohaghegh@yahoo.com
Abstract:   (16447 Views)

Background: According to evidence of therapeutic effects of Komboucha, this study was conducted to investigate the effects of Kombucha topical application Synchronized with Kombucha tea oral administration on third-degree burn wounds healing in Wistar rats. Materials and Methods: In this experimental study, forty Wistar male rats weighing 150-200g were subjected to the deep-burn wounds under general anesthesia in the sterile condition. They were randomly divided into four groups including control (the group without any treatment), sham (sweetened tea treated group), experimental1 (KT treated group) and experimental2 (the group that treated with KT oral administration and homogeneous Kombucha symbiont topical application). After 21-day treatment, the rats were sacrificed using an overdose of anesthetic. Macroscopic and microscopic characteristics of wound were studied.
 Results: Macroscopic evaluation revealed completely closure of burn wounds in experimental groups. Histological studies showed that skin, keratinocyte layer, epidermis and hypodermis thicknesses in the experimental 1 and experimental 2 groups and also number and diameter of hair follicles in the experimental 1 group were significantly increased compared with the control group (P<0.001).
Conclusion: Synchronized oral administration and topical application of Kombucha probably lead to healing acceleration and scar reduction of full-thickness burn wounds.

Keywords: Kombucha tea, Homogeneous Kombucha symbiont, Healing, Third degree burn, Rat
Full-Text [PDF 1559 kb]   (2121 Downloads)    
Type of Study: Experimental | Subject: Animal Biology
Received: 2012/04/3 | Accepted: 2016/12/31 | Published: 2016/12/31
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parivar K, Yaghmaie P, Hayati Rudbari N, Mohammadi Mohaghegh P. Effects of synchronized oral administration and topical application of Kombucha on third-degree burn wounds regeneration in mature rats. MEDICAL SCIENCES. 2012; 22 (1) :1-11
URL: http://iau-tmuj.ir/article-1-535-en.html
Volume 22, Number 1 (spring2012 2012) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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