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:: Volume 27, Number 1 (spring 2017) ::
MEDICAL SCIENCES 2017, 27(1): 1-8 Back to browse issues page
Evaluation of antiviral effects of sumac (Rhus coriaria L.) fruit extract on acyclovir resistant Herpes simplex virus type 1
Masoud Parsania *1, Mohammad Bagher Rezaee2, Seyed Hamidreza Monavari3, Kamkar Jaimand3, Seyed Milad Mousavi Jazayeri, Mehdi Razazian, Mohammad Hossein Nadjarha
1- Assistant Professor , mparsania@iautmu.ac.ir
2- Professor
3- Associate Professor
Abstract:   (855 Views)
Background: Herpes simplex virus type 1 (HSV-1) is a common virus in human. The rate of drug resistance is increasing in HSV-1. In this study, anti-viral effects of Rhus coriaria L. fruit extract was evaluated against acyclovir resistant HSV-1 before, during and after the infection of Hela cell line. Materials and methods: In this experimental study, the trypan blue and 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide (MTT) tests were used to rule out the potential toxic effects extract on the Hela cell line. Antiviral effects of the extract on acyclovir resistant HSV-1 were evaluated before the infection and at different concentrations of the extract. The effective minimal cytotoxic concentration was assessed at different times of virus replication after virus adsorption. Virus titer was determined by tissue culture infectious dose 50 (TCID50) method. Results: The CC50 value and effective minimal cytotoxic concentration were determined at 780 µg/ml and 390 µg/ml respectively. Treatment of HSV-1 with extract resulted in 1 log10 TCID50 reduction in virus titers after 3 and 4 hour. The highest reduction in acyclovir resistant HSV-1 infectivity was obtained 2 and 4 hour after the infection of the cells with virus resulting in 1.7 log10 TCID50 reduction as compared with control. Conclusion: The antiviral effects of Rhus coriaria L. fruit extract on acyclovir resistant HSV-1 after virus infection was more remarkable than the treatment of virus with the extract before virus adsorption. Keywords: Sumac extract, Antiviral effects, Herpes simplex virus type 1.
Keywords: Sumac extract, Antiviral effects, Herpes simplex virus type 1
Full-Text [PDF 347 kb]   (363 Downloads)    
Type of Study: Experimental | Subject: Virology
Received: 2016/07/16 | Accepted: 2016/10/22 | Published: 2017/04/1
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Parsania M, Rezaee M B, Monavari S H, Jaimand K, Mousavi Jazayeri S M, Razazian M et al . Evaluation of antiviral effects of sumac (Rhus coriaria L.) fruit extract on acyclovir resistant Herpes simplex virus type 1. MEDICAL SCIENCES. 2017; 27 (1) :1-8
URL: http://iau-tmuj.ir/article-1-1211-en.html
Volume 27, Number 1 (spring 2017) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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