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Validation study of IgG antibodies by ELISA for the detection of Helicobacter pylori infection in comparison with pathologic findings in hemodialysis patients with dyspepsia
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Maryam Yarmohammadi1   , Mohammad Bagher Sohrabi 2, Pouneh Zolfaghari3 , , Nasim Nikkheslat4 , Elaheh Yahyaei5 , Batoul Daghyanous6 |
1- Pathologist, Department of Pathology, Imam Hossein Hospital, Shahroud University of Medical Science, Shahroud, Iran
2- Researcher, General Practitioner, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran , mb.sohrabi@yahoo.com
3- Researchers, General Practitioner, Vice-chancellery of Health, Shahroud University of Medical Sciences, Shahroud, Iran
4- Researchers, BSc of Family Health, Vice-chancellery of Health, Shahroud University of Medical Sciences, Shahroud, Iran
5- Researcher, BSc of Management, Clinical Research Office, Imam Hossein Hospital, Shahroud University of Medical Science, Shahroud, Iran
6- Researcher, BSc of Nursing, Researcher, Clinical Research Office, Imam Hossein Hospital, Shahroud University of Medical Science, Shahroud, Iran |
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Abstract: (5735 Views) |
Background: Helicobacter pylori infection is a major cause of chronic gastritis in hemodialysis patients. There are various methods for diagnosis of infections with this organism. This study compared two methods of histology and serology for diagnosis of Helicobacter pylori in hemodialysis patients.
Materials and methods: This study has been done on 75 hemodialysis patients with dyspepsia referred to Imam Hossain Hospital of Shahroud, Iran in 2014. Endoscopy with standard biopsy and serology test were done for all patients. Sensitivity, specificity, and positive and negative predictive value were evaluated for serology test.
Results: From 75 patients with dyspepsia, 49 patients (65.3%) had positive serology test, and 64 (85.3%) patients were positive by histologic findings. Sensitivity, specificity, positive predictive value, and negative predictive value were 70.3%, 63.6%, 91.8% and 26.9%, respectively.
Conclusion: Due to the relative high sensitivity and specificity of serological tests in comparison with other diagnostic methods, as well as its simplicity, speed and low cost, it is recommended to use this test for screening of hemodialysis patients.
Keywords: Helicobacter pylori, Hemodialysis, Serology, Histology, Sensitivity, Specificity. |
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| Keywords: Helicobacter pylori, Hemodialysis, Serology, Histology, Sensitivity, Specificity. |
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Full-Text [PDF 180 kb]
(2951 Downloads)
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Semi-pilot: Survey/Cross Sectional/Descriptive |
Subject:
Pathology
Received: 2015/08/8 | Accepted: 2015/12/27 | Published: 2016/09/17
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Yarmohammadi M, Sohrabi M B, Zolfaghari P, Nikkheslat , N, Yahyaei E, Daghyanous B. Validation study of IgG antibodies by ELISA for the detection of Helicobacter pylori infection in comparison with pathologic findings in hemodialysis patients with dyspepsia. MEDICAL SCIENCES 2016; 26 (3) :200-205 URL: http://tmuj.iautmu.ac.ir/article-1-1136-en.html
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