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:: Volume 26, Issue 3 (fall 2016) ::
MEDICAL SCIENCES 2016, 26(3): 149-156 Back to browse issues page
Evaluation of neuroprotective effect of propofol on pyramidal neurons in CA1 region of hippocampus among male lab rats following ischemia/ transient overall reperfusion
Delaram Farhangi 1, Zahra Nadia Sharifi2 , Shabnam Movassghi3 , Hossein Bahadoran4 , Samaneh Kalantary5
1- BS in Anesthesiology, Young Researchers and Elite Club, Tehran Medical sciences Branch, , Islamic Azad University, Tehran, Iran , farhangi.dm90@gmail.com
2- PhD in Neuroscience, Tehran Medical sciences Branch, , Islamic Azad University, Tehran, Iran
3- PhD in Anatomy, Tehran Medical sciences Branch, , Islamic Azad University, Tehran, Iran
4- Department of Anatomy, Faculty of Medicine, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
5- BS in biochemistry, Research Institute for Islamic& Complementary Medicine, Tehran , Iran
Abstract:   (5475 Views)

Background: Ischemic stroke creates irreparable damages in patients with cerebrovascular disease. The CA1 region in hippocampus is one of the most sensitive areas of brain to ischemia. The recent reports have considered administrating propofol, as a neuroprotective agent. This study evaluated the neuroprotective effects of propofol on CA1 region of hippocampus on male lab rats following ischemia/ transient overall reperfusion in the empirical models.

Materials and methods: In this experimental study, 18 male Wistar rats were divided randomly into three groups, each containing 6 rats to serve as control, ischemia and test subjects. Propofol in 40mg/kg dose was injected intraperitoneal, 1 hour before ischemia. The ischemia model was performed by bilateral blockage of common carotid arteries for 20 minutes. The Hematoxylin-Eosin, Nissl and TUNEL methods were used for evaluating histomorphologic changes, the changes in number of cells and the apoptotic bodies.

Results: Injecting 40mg/kg propofol revealed protective characteristics on hippocampal pyramidal neurons of the ischemia/reperfusion induced lab rats.

Conclusion: Ischemia causes death of neurons and morphological changes, while injecting propofol is able to significantly reduce the death of neurons and protect neurons against ischemic damages.

Keywords: Neuroprotective.  Propofol.  Hippocampus.  Ischemia–reperfusion. Rat.

Keywords: Neuroprotective. Propofol. Hippocampus. Ischemia–reperfusion. Rat.
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Semi-pilot: Experimental | Subject: Anesthesiology
Received: 2015/12/13 | Accepted: 2016/02/21 | Published: 2016/09/17
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Farhangi D, Sharifi Z N, Movassghi S, Bahadoran H, Kalantary S. Evaluation of neuroprotective effect of propofol on pyramidal neurons in CA1 region of hippocampus among male lab rats following ischemia/ transient overall reperfusion . MEDICAL SCIENCES 2016; 26 (3) :149-156
URL: http://tmuj.iautmu.ac.ir/article-1-1129-en.html


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Volume 26, Issue 3 (fall 2016) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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