[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 25, Issue 1 (Spring 2015) ::
MEDICAL SCIENCES 2015, 25(1): 1-15 Back to browse issues page
Pharmacogenomics and cancer stem cells
Mohammad Reza Noori-Daloii 1, Nader Ebadi2
1- Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , nooridaloii@sina.tums.ac.ir
2- MSc Student of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (9122 Views)
In oncology, Pharmacogenomics is still considered to be the best strategy to personalize cancer therapy. Although, its clinical application is still limited to a few genes, And also in a number of cancers, the correlation between genotype and clinical outcome have been promising. However, since the current pharmacogenomic studies do not take into account the emerging role of cancer stem cells (CSCs) in drug sensitivity and resistance, Favorable results were not achieved. CSCs are the only tumor-initiating cells within a malignancy due to this CSCs are at the apex of human cancer hierarchy system. But genetic variants affecting their activity in some specific signal-transduction pathways are generally neglected in current pharmacogenomic studies. Moreover, in several malignancies, CSCs represent a rare sub-population therefore, whole tumor profiling might mask CSC gene expression patterns. This article reviews current evidence on CSC chemoresistance and shows how common genetic variations in CSC-related genes may predict individual response to anticancer agents. Furthermore, this article provides insights into the design of pharmacogenomic studies to address the clinical usefulness of CSC genetic profiling.
Keywords: Pharmacogenomics, Cancer, Cancer stem cells
Full-Text [PDF 758 kb]   (10357 Downloads)    
Semi-pilot: Review | Subject: Genetic
Received: 2015/03/9 | Accepted: 2015/03/9 | Published: 2015/03/9
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Noori-Daloii M R, Ebadi N. Pharmacogenomics and cancer stem cells. MEDICAL SCIENCES 2015; 25 (1) :1-15
URL: http://tmuj.iautmu.ac.ir/article-1-899-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 25, Issue 1 (Spring 2015) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
Persian site map - English site map - Created in 0.07 seconds with 37 queries by YEKTAWEB 4645