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:: Volume 24, Issue 4 (winter 2015) ::
MEDICAL SCIENCES 2015, 24(4): 221-226 Back to browse issues page
Effects of niasine on serum phosphorus, PTH and lipid profile in the hemodialysis patients in Shahroud city
Monireh Amerian1 , Mohammad Bagher Sohrabi 2, Pooneh Zolfaghari3 , Maryam Yarmohammadi4 , Ehsan Nezakati5 , Elaheh Yahyaei6 , Maryam Mahdavian7 , Javad Sarrafha7
1- Nephrologist, Department of Nephrology, Imam Hossein Hospital, Shahroud University of Medical Science, Shahroud, Iran
2- General Practitioner, Researcher, Imam Hossein Hospital, Shahroud University of Medical Science, Shahroud, Iran , mb.sohrabi@yahoo.com
3- General Practitioner, Researcher, Imam Hossein Hospital, Shahroud University of Medical Science, Shahroud, Iran
4- Pathologist, Department of Pathology, Imam Hossein Hospital, Shahroud University of Medical Science, Shahroud, Iran
5- Specialist of Infectious Diseases, Department of Infectious Diseases, Imam Hossein Hospital, Shahroud University of Medical Science, Shahroud, Iran
6- BSc of Management, Researcher, Imam Hossein Hospital, Shahroud University of Medical Science, Shahroud, Iran
7- BSc of Nursing, Researcher, Imam Hossein Hospital, Shahroud University of Medical Science, Shahroud, Iran
Abstract:   (6717 Views)
Background: Control of the phosphorus, parathyroid hormone, and serum lipids in dialysis’ patients is very important and can be done in many ways. The purpose of the study was to determine the effect of niacin on the serum phosphorus, parathyroid hormone and lipid profile among hemodialysis patients.
Materials and methods: This double blind controlled randomized study was done on 120 dialysis patients whom were divided into two groups: 60 patients (taking niacin) and 60 patients as control groups (taking placebo). Niacin was prescribed as increasing dose from 200 mg to 600 mg monthly in three steps. Phosphorus, PTH and lipid profile were measured in the both groups. P-value<0.05 was considered as significant.
 Results: 40 patients of case group (66.7%) and 37 patients (61.7%) of control group were male. Niacin significantly decreased serum levels of phosphorus (p<0.001) and parathyroid hormone (PTH) (p<0.001), also it significantly increased serum levels of HDL (p<0.01). Conclusion: Nicotinic acid can decrease serum phosphorous and PTH level, and increase HDL cholesterol level. However, it needs a well design and larger trial study for determining the most effective doses of the nicotinic acid.
Keywords: Niacin, Serum phosphorous, PTH, Lipid profile, Hemodialysis
Full-Text [PDF 128 kb]   (2301 Downloads)    
Semi-pilot: Experimental | Subject: Infectious Diseases
Received: 2014/12/20 | Accepted: 2014/12/20 | Published: 2014/12/20
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Amerian M, Sohrabi M B, Zolfaghari P, Yarmohammadi M, Nezakati E, Yahyaei E, et al . Effects of niasine on serum phosphorus, PTH and lipid profile in the hemodialysis patients in Shahroud city. MEDICAL SCIENCES 2015; 24 (4) :221-226
URL: http://tmuj.iautmu.ac.ir/article-1-869-en.html


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Volume 24, Issue 4 (winter 2015) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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