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Effect of Salvia officinalis L. extract on malondialdehyde against streptozotocin-induced oxidative stress in rat’s brain
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Shahram Shahmohamadi1   , Maryam Khosravi 2, Akbar Hajizadeh Moghaddam3 |
1- MSc Student of Animal Physiology, Department of Biology, Faculty of Biology, Islamic Azad University, Tehran North Branch, Tehran, Iran
2- Department of Biology, Faculty of Biology, Islamic Azad University, Tehran North Branch, Tehran, Iran , maryam.khosravi@yahoo.com
3- Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran |
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Abstract: (11115 Views) |
Background: Oxidative stress is caused by an imbalance between oxidative and the anti-oxidative systems in the living tissues. Oxidative stress in brain causes brain dysfunction, destruction of neurons, and diseases like Alzheimer. In the present study, we examined the protective effect of Salvia officinalis L. against streptozotocin-induced oxidative stress in rat’s brain.
Materials and Methods: In this experimental study, Wistar rats were divided into control, Sham, and three experimental groups received 25, 50 and 100 mg/kg hydroalcoholic extract of Salvia officinalis intraperitoneally, respectively. After two weeks, surgical procedure was performed on sham and experimental groups and after one week recovery, streptozotocin was injected intra-cerebroventricularly (ICV-STZ) at 3 mg/kg. Brain hemispheres were collected after fourth week. Finally, malondialdehyde (MDA)) level was measured in brain hemispheres tissues.
Results: STZ significantly increased MDA levels compared to the control group (P<0.001), whereas intraperitoneally injection of different doses of Salvia officinalis leaves extract significantly decreased MDA levels (P<0.001).
Conclusion: We concluded that antioxidant effect of Salvia officinalis L. could prevent oxidative stress induced by ICV injection of STZ in the brain of male rat. |
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| Keywords: Oxidative stress, Salvia officinalis, Streptozotocin, Malondialdehyde, Rat |
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Full-Text [PDF 186 kb]
(6286 Downloads)
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Semi-pilot: Experimental |
Subject:
Physiology
Received: 2013/12/15 | Accepted: 2013/12/15 | Published: 2013/12/15
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