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Factors affecting pregnancy and abortion rates following intra cytoplasmic sperm injection in the obstructive and non-obstructive azoospermic men
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Elhamossadat Hashemian Naeini1   , Firoozeh Akbari asbagh2 , Mohammad Zare Niyestanak3 , Abdolrasool Mehrsay4 , Elham Foroozandeh5 , Mostafa Shokoohi6 , , Katayoun Berjis 7 |
1- Gynecologist and Obstetrician, Mirza Koochak Khan Hospital, Tehran, Iran
2- Gynecologist and Obstetrician, Tehran University of Medical Sciences, Tehran, Iran
3- PhD Candidate of Psychology, Islamic Azad University, Naeen Branch, Naeen, Iran
4- Urologist, Tehran University of Medical Sciences, Tehran, Iran
5- PhD of Psychology, Islamic Azad University, Naeen Branch, Naeen, Iran
6- MSc of Epidemiology, Kerman University of Medical Sciences, Kerman, Iran
7- Gynecologist and Obstetrician, Fellowship of Infertility, Boo-Ali Hospital, Tehran, Iran , katayon.berjis@yahoo.com |
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Abstract: (15923 Views) |
Background: Intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of azoospermic men. The aim of this study was to evaluate the factors interfering in the success of ICSI, including sperm collection method, testicular histology, age and hormonal assay of the couple, the number of retrieved oocytes, and the number of transferred embryos.
Materials and methods: In this retrospective cohort study, 246 azoospemic men (52 with obstructive azoosprmia (OA) and 194 with non obstructive azoospermia (NOA)) who were underwent sperm retrieval with PESA or TESE and ICSI protocol were studied. By long protocol of ovarian stimulation, oocytes were retrieved 36h after hCG administration. After 48h, cleaved embryos were replaced in the uterine cavity.
Results: Clinical pregnancy rates (21.1% in OA versus 10.8% in NOA) was significantly correlated with sperm origin (P<0.05). Female partner’s age and serum FSH significantly influenced pregnancy rates in both groups (p<0.001) and also pregnancy rates was significantly influenced by number of retrieved oocytes and transferred embryos in NOA groups (P<0.05).
Conclusion: ICSI can make a chance for fertility in azoospermic men. Higher success rates in OA patients can be related to better quality of sperm. The value of male hormonal assay and testicular biopsy was not remarkable. |
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| Keywords: Obstructive azoosprmia, Non obstructive azoospermia, ICSI, Clinical pregnancy rates |
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Full-Text [PDF 162 kb]
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Semi-pilot: Cohort |
Subject:
Gynecology
Received: 2012/09/23 | Published: 2012/09/15
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