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Effect of zinc on diabetes in diabetic male rat offsprings
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Parichehr Yaghmaei   1, Hamideh Esfahani Nejad2 , Nasim Hayati Roodbari3 , Ramesh Ahmadi4 |
1- Department of Animal Biology, Islamic Azad University, Science and Research Campus, Tehran, Iran , yaghmaei_p@yahoo.com
2- MSc of Physiology, Islamic Azad University, Science and Research Campus, Tehran, Iran
3- Department of Animal Biology, Islamic Azad University, Science and Research Campus, Tehran, Iran
4- Department of Animal Biology, Islamic Azad University, Qom Branch, Qom, Iran |
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Abstract: (19597 Views) |
Background: Zinc plays a clear role in the synthesis, storage and secretion of insulin. In this study, effect of zinc intake by pregnant rats on their diabetosized offspring was investigated.
Materials and methods: In this experimental study, pregnant rats were divided in two groups. Control group received normal food and water during pregnancy and after birth, and experimental group received zinc sulphate along this time. Male offsprings from control group were divided in three groups: C1: with normal food and water, C2: diabetosized and C3: received zinc sulphate. Male offsprings from experimental group were divided in four groups: exp1: with normal food and water, exp2: diabetosized, exp3: received zinc sulphate and exp4: diabetosized and received zinc sulphate. Treatment continued for 30 days and water and food intake and urine quantity were measured per day for offsprings. Also, weight, blood glucose and insulin level were detetmined.
Results: Water intake and urine quantity were decreased significantly in exp2 and exp4 (experimental diabetic groups) in comparison with C2 (control diabetic group) (both p<0.01). Body weight was not significantly different between C2 group and exp2 and exp4 groups. Blood glucose was decreased significantly (p<0.001) in exp2 and exp4 in comparison with C2 and blood insulin level was increased significantly (p<0.01, p<0.001) in exp2 and exp4 in comparison with C2.
Conclusion: Zinc intake has useful effects on the control of diabetes and it decreases the symptoms of diabetes. |
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| Keywords: Diabetes, Rat offsprings, Zinc sulphate, Glucose, Insulin |
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Full-Text [PDF 356 kb]
(2851 Downloads)
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Semi-pilot: Experimental |
Subject:
Animal Biology
Received: 2012/04/3 | Published: 2012/04/15
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