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:: Volume 21, Issue 4 (winter 2012) ::
MEDICAL SCIENCES 2012, 21(4): 268-274 Back to browse issues page
Histological, histometrical and thyroid hormones serum level evaluation after chronic nicotine exposure in mice
Simin Fazelipoor * 1, Mahsa Hadipour Jahromi 2, Negar Behtash 3, Zahra Tootiyan 4, Minoo Shafie 5, Fardin Asadi 6, Hamid Reza Chegini 7
1- Associate Professor, Department of Anatomy, Islamic Azad University, Tehran Medical Branch, Tehran, Iran , simin_fazelipour@yahoo.com
2- Associate Professor, Department of Pharmacology, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
3- Medical Student, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
4- Associate Professor, Department of Anatomy, Faculty of Veterinary, Tehran University, Tehran, Iran
5- Assistant Professor, Department of Pathology, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
6- Assistant Professor, Department of Pediatrics, Zanjan University of Medical Sciences, Zanjan, Iran
7- Instructor, Department of Anatomy, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
Abstract:   (17259 Views)
Background: Nicotine is an ingredient of cigarette smoke that has a lot of psychological and physical effects on addicted persons. The aim of this study was to evaluate nicotine effects on functional and histological alteration in thyroid gland that has important role on metabolic activities.
Materials and methods: In this experimental study, 40 mature male mice (25-30 gr) were divided to one control group and 3 experimental groups that received nicotine with dosage of 100, 200 and 400 µg/kg via oral gavage once a day for 60 days. Then, T3, T4 and TSH serum levels were measured and histomorphometric evaluation of thyroid gland was done.
Results: Significant decrease in body weight and thyroid follicular epithelial height and significant increase in serum level of T3 were noted.
Conclusion: This study showed that nicotine can cause alteration on metabolic activities of thyroid gland via the increase of T3 serum level and the decrease of follicular epithelial height.
Keywords: Nicotine, Thyroid, Histology, Histometry
Full-Text [PDF 488 kb]   (1350 Downloads)    
Type of Study: Experimental | Subject: Anatomy
Received: 2012/02/15
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Fazelipoor S, Hadipour Jahromi M, Behtash N, Tootiyan Z, Shafie M, Asadi F et al . Histological, histometrical and thyroid hormones serum level evaluation after chronic nicotine exposure in mice. MEDICAL SCIENCES. 2012; 21 (4) :268-274
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Volume 21, Issue 4 (winter 2012) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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