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:: Volume 21, Issue 3 (fall 2011) ::
MEDICAL SCIENCES 2011, 21(3): 151-161 Back to browse issues page
Roles of miRNAs in gene expression regulation, apoptosis, diagnosis and treatment of cancer
Mohammad Reza Noori-Daloii * 1, Fatemeh Vand Rajabpour 2
1- Professor Tehran University of Medical Sciences, Tehran, Iran , nooridaloii@sina.tums.ac.ir
2- MSc Student Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (23656 Views)
Apoptosis, as a programmed cell death, is activated in response to various stresses. Apoptosis is an active and energy need process that many mechanisms and genetic factors control it with specific programs. Apoptotic cells have specific features. Apoptosis acts in many different organic evolutionary stages. Aberrations in regulation of this process can cause many diseases, such as cancers. Different molecules, like miRNAs, have a role in apoptosis process. miRNAs, as regulatory molecules, act in abundant cellular mechanisms. Regarding their function, apoptotic related miRNAs were divided in proapoptotic and antiapoptotic groups. miRNAs target several mRNAs and also themselves were regulated by other genes. This regulatory loop between miRNAs and related genes cause complexity. miRNAs have different expression profile in normal and abnormal cells. Apoptosis and miRNA both act in different processes of tumorigenesis, metastasis and antiogenesis. miRNAs can be used as biomarkers in prevention, prognosis and prevention of different cancers. Advances in knowledge about miRNAs lead to develop new therapeutic trend. Recent researches have suggested using miRNAs involved in apoptosis in the treatment of cancers.
Keywords: Apoptosis, miRNA, Cancer, Proapoptotic, Antiapoptotic, Mirtron
Full-Text [PDF 307 kb]   (6759 Downloads)    
Type of Study: Review | Subject: Genetic
Received: 2011/11/27 | Accepted: 2013/06/30 | Published: 2013/06/30
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Noori-Daloii M R, Vand Rajabpour F. Roles of miRNAs in gene expression regulation, apoptosis, diagnosis and treatment of cancer. MEDICAL SCIENCES. 2011; 21 (3) :151-161
URL: http://iau-tmuj.ir/article-1-492-en.html


Volume 21, Issue 3 (fall 2011) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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