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Association of Cag A positive Helicobacter pylori with bacterial colonization and epithelial immune response
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Mehran Ragha1   , Mina Rezaei2 , Zahra Poormoghaddas 3, Keyvan Shirneshan4 , Mahmood Jannatipoor5 |
1- Islamic Azad University, Najafabad
2- Islamic Azad University, Najafabad, Iran
3- Islamic Azad University, Najafabad, Iran , zahrapormoghadas@yahoo.com
4- Dr. Ali Shariati Hospital, Isfahan
5- Isfahan University of Medical Sciences, Isfahan, Iran |
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Abstract: (21671 Views) |
Background: This study was conducted to assess the association of CagA (Cytotoxin associated gene A) positive Helicobacter pylori (H. pylori) with bacterial colonization and immune response in gastric epithelial cells.
Materials and methods: Gastric biopsy specimens of angulus, antrum, and lesser and greater curvatures were obtained from 138 patients with dyspeptic symptoms referred for endoscopy to Shariati Hospital, Isfahan. Specimens were evaluated for H. pylori and in positive ones, serum samples were investigated for anti-CagA IgG antibody. Immune response to Helicobacter pylori was classified according to Sydney system.
Results: Of138 patients, 97 (70.3%) were infected with H. pylori from which CagA antibody was positive in 83.5%. No association was found between CagA positive antibody and age or gender (P>0.05). Also, no association was found between CagA status and bacterial colonization or epithelial immune response (P>0/05).
Conclusion: The presence of CagA positive H. pylori is not related to bacterial colonization or gastric epithelial immune response in dyspeptic patients. However, according to evidence on the association of CagA positive H. pylori with increased of gastric cancers, strict follow-up of patients with this type of H. pylori is recommended even in the absence of severe epithelial immune response.
Keywords: Helicobacter pylori, CagA antibody, Colonization, Immune response. |
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| Keywords: Helicobacter pylori, CagA antibody, Colonization, Immune response |
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Full-Text [PDF 465 kb]
(4507 Downloads)
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Semi-pilot: Survey/Cross Sectional/Descriptive |
Subject:
Gastrology
Received: 2011/07/5 | Published: 2011/06/15
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