Factors influencing the success rate in leukocyte immunization among patients with recurrent miscarriage
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Chaichian Sh 1, Shoaie Sh , Pedar S , Saremi A |
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Abstract: (28545 Views) |
Background: Spontaneous abortion is the most common pregnancy-related complication. Paternal-induced immunization has been postulated as a treatment modality. The present study was conducted to evaluate the efficacy of this technique in patients with recurrent miscarriage.
Materials and methods: During this historical cohort study, medical records of 549 patients underwent leukocyte immunization in Sarem Infertility Center due to recurrent miscarriage were studied. WBC crossmatch was performed two weeks following the last injection in order to quantify anti-paternal cytotoxic anti body (APCA). Initial data were gathered using a questionnaire. Results: WBC crossmatch was positive in 93 patients (16.9%). Among these patients, 60 (64.5%) had documented pregnancy by β-HCG and 49 (81.7%) had clinical success (gestational age more than 28 weeks). Logistic regression has revealed that number of children had the most powerful significant correlation with positive WBC crossmatch. Meanwhile, consanguinity was inversely associated with WBC crossmatch positive results.
Conclusion: Immunization-induced anti-paternal cytotoxic antibody production is associated with better pregnancy outcome. Our response rate was in agreement with prior studies, however, further researches are strongly suggested. |
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Keywords: Leukocyte immunization, Recurrent miscarriage, Anti-paternal cytotoxic antibody (APCA) |
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Subject:
Nutrition Sciences Received: 2006/09/6 | Published: 2005/04/15
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