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:: Volume 28, Issue 3 (spring 2018) ::
MEDICAL SCIENCES 2018, 28(3): 207-211 Back to browse issues page
Albendazole induces cell death in human colorectal cancer cell line HT-29
Elham Hoveizi * 1, Tayebeh Mohammadi 2
1- Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran - Stem cells and Transgenic Technology Research Center (STTRC), Shahid Chamran University of Ahvaz, Ahvaz, Iran , e.hoveizi@yahoo.com
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Kermanshah, Iran
Abstract:   (140 Views)
Background: It is a continuing effort to develop new anticancer drugs.  It has been reported that albendazole has antiproliferative effects on several tumor cell lines. The aim of this study was to evaluate the killing effect of albendazole on HT-29 human colorectal cancer cells.
Materials and methods: Cultured HT-29 cells were treated with albendazole in 0.1, 1 and 10 µg/ml concentrations for 1, 3 and 5 days. Cellular viability and proliferation were evaluated by MTT and Trypan blue assays at determined days after treatment.  
Results: The comparison of cells count and viability in control group and treated groups with albendazole at different concentrations showed significant differences in days 1, 3 and 5.
Conclusion: Albendazole can suppress HT-29 cells proliferation and induces cell death in a dose and time dependent manner.
 
Keywords: Albendazol, MTT, Cancer, Cell death.
Keywords: Albendazol, MTT, Cancer, Cell death.
Full-Text [PDF 158 kb]   (32 Downloads)    
Type of Study: Experimental | Subject: Molecular Biology
Received: 2018/03/11 | Accepted: 2018/05/7 | Published: 2018/09/22
ENG-PDF [PDF 592 KB]  (10 Download)
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Hoveizi E, Mohammadi T. Albendazole induces cell death in human colorectal cancer cell line HT-29 . MEDICAL SCIENCES. 2018; 28 (3) :207-211
URL: http://iau-tmuj.ir/article-1-1442-en.html


Volume 28, Issue 3 (spring 2018) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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