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:: Volume 28, Issue 2 (winter 2018) ::
MEDICAL SCIENCES 2018, 28(2): 81-91 Back to browse issues page
Protective effects of vitamin E on sperm characteristics and some serum parameters in mice toxicity induced by dianabol
Mohammad Babaei 1, Zahra Tootian * 2, Hassan Morovvati 3, Bahador Shojaei 4, Simin Fazelipour 5
1- PhD Student, Department of Anatomy & Embryology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
2- Professor Department of Anatomy & Embryology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran , ztotian@ut.ac.ir
3- Professor Department of Comparative Histology & Embryology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
4- Professor Department of Anatomy & Embryology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
5- Professor Department of Anatomy, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Abstract:   (130 Views)
Background: Anabolic steroid drugs, especially dianabol, were used as energy producer drug for growth and enhancement of muscles in athletes. Using of anabolic-androgenic steroids among athletes is extended. However, there are limited information about the adverse effects of mentioned drugs on genital system. This study aimed to evaluation of protective effects of vitamin E against damages caused by dianabol on male genital system.
Materials and methods: In this experimental study, 72 male mice grouped randomly to one control group and seven experimental groups (n=9). Mice in experimental groups 1, 5, 6 and 7 received vitamin E with dose 100 IU/kgBW. Experimental groups 5, 6 and 7 were administrated dianabol with doses 5, 10 and 20 mg/kgBW after 4 hours of vitamin E reception. Mice in experimental groups 2, 3 and 4 received just dianabol with doses 5, 10 and 20 mg/kgBW. Administration method in all groups was orally by gavage for 42 days. 24 hours after last treatment, blood samples were collected from heart and sperm characteristics were evaluated.
Results: Results showed significant decrease in total antioxidant capacity (TAC) and increase in malondialdehyde (MDA) in serum; vitamin E administration remarkably improved above mentioned parameters. Also, vitamin E administration caused improvement in sperm parameters and blood testosterone level.
Conclusion: This study showed that vitamin E, as inhibitor of free radical, can decrease oxidative damages caused by dianabol.
Keywords: Vitamin E, Dianabol, Sperm, Testosterone, Mice
Full-Text [PDF 316 kb]   (50 Downloads)    
Type of Study: Experimental | Subject: Anatomical Sciences
Received: 2018/01/14 | Accepted: 2018/01/31 | Published: 2018/06/19
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Babaei M, Tootian Z, Morovvati H, Shojaei B, Fazelipour S. Protective effects of vitamin E on sperm characteristics and some serum parameters in mice toxicity induced by dianabol . MEDICAL SCIENCES. 2018; 28 (2) :81-91
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Volume 28, Issue 2 (winter 2018) Back to browse issues page
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران Medical Science Journal of Islamic Azad Univesity - Tehran Medical Branch
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