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Effects of Avicennia marina fruits aqueous and hydro alcoholic extract on streptozotosin –induced diabetic male rats
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Liela Kamaei   1, Hadi Fathi Moghaddam , Mokhtar Mokhtari , Seyyed Ali Mard , Davood Moghadamnia , Davood Moghadamnia |
| 1- , Leila.Kamaei@yahoo.com |
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Abstract: (4566 Views) |
| Background: Diabetes mellitus is a major endocrine disorder and growing health problem in most countries. We studied effects of Avicennia marina fruits aqueous and hydroalcoholic extract in the diabetic rat by streptozotocin.
Materials and methods: In this experimental study, 45 male rats were divided into 9 groups of 5, including sham group, diabetes sham, positive sham (diabetes + 0.9% normal saline) and treated diabetic groups orally with aqueous and hydroalcoholic extract of Avicennia marina fruits (30, 60, 120 mg/kg daily for three consecutive days). Twenty-four hours after the last treatment rats, blood samples were collected from heart for determining the blood glucose and insulin concentration levels using glucose oxidase and enzyme-linked immunosorbent assay (ELISA) methods respectively.
Results: All doses of Avicennia marina fruits aqueous and hydroalcoholic extract significantly decreased serum glucose level of diabetic test rats compared to treated diabetic sham rats. 60mg/kg of Avicennia marina fruits hydroalcoholic extract and all doses of Avicennia marina fruits aqueous extract significantly increased serum insulin level of diabetic test rats compared to treated diabetic sham rats.
Conclusion: In this study, we have shown that Avicennia marina fruits aqueous and hydroalcoholic extract can significantly decrease the blood glucose.
Keywords: Avicennia marina, Diabete, Blood glucose, Insulin. |
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| Keywords: Avicennia marina, Diabete, Blood glucose, Insulin. |
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Full-Text [PDF 269 kb]
(2618 Downloads)
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Semi-pilot: Experimental |
Subject:
Physiology
Received: 2016/07/6 | Accepted: 2016/09/13 | Published: 2017/04/1
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